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Confusion over tiredness
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<blockquote data-quote="faujidoc1" data-source="post: 1509526" data-attributes="member: 419625"><p>The 300g carb/day is the US FDA recommendation for a balanced diet for a normal healthy adult taking 2000 Cal/day. I don't mean to suggest that this number is inviolate or necessarily correct for a diabetic.</p><p>Of course, many people are fine with much less, and this is especially true for diabetics.... No argument there!</p><p>Yes, tiredness after starting insulin and normalizing BS could be due to the effect of stress hormones, associated thyroid or vitamin deficiency etc.</p><p>Yet there are many reports on this forum, such as that of the OP who have tiredness for years, for no obvious cause. All investigations are normal, they are not in depression, their BS is well controlled...So why?</p><p>I also read a few reports where people switched the basal insulin from Glargine to Determir (and vice versa too) and the tiredness vanished! This lead me to think that in those having tiredness for no obvious reason, perhaps the response of the body to insulin is the reason.</p><p>Does the tiredness indicate insufficient calorie intake? If the T1 is taking sufficient calories orally (I won't quibble over the carb/protein/fat ratios) ... then does the tiredness indicate the insufficient uptake of the ingested calories due to a relative deficiency in the action of the basal insulin in this particular person? Remember, insulin is required for the cells to actually be able to metabolize glucose, irrespective of whether the glucose came from carbs, protein or fat. Switching the type of basal insulin would then entail a different drug response and perhaps better relative efficacy.... This would explain why some people cured their tiredness by switching the insulin.</p><p>Another way might be to increase the dose of insulin to make more calories 'available' to the body. But that would lead to dipping BS, which would have to be offset by increasing the intake of carbs/ protein/fat... I chose carbs as it was the easiest way to explain without getting into the nitty gritty of gluconeogenesis!</p><p>Like I said, only a theory... I was just trying to figure out why an apparently perfectly treated T1 with no other identifiable comorbidity should feel tired for years. </p><p>Peace!</p><p>[emoji255]</p></blockquote><p></p>
[QUOTE="faujidoc1, post: 1509526, member: 419625"] The 300g carb/day is the US FDA recommendation for a balanced diet for a normal healthy adult taking 2000 Cal/day. I don't mean to suggest that this number is inviolate or necessarily correct for a diabetic. Of course, many people are fine with much less, and this is especially true for diabetics.... No argument there! Yes, tiredness after starting insulin and normalizing BS could be due to the effect of stress hormones, associated thyroid or vitamin deficiency etc. Yet there are many reports on this forum, such as that of the OP who have tiredness for years, for no obvious cause. All investigations are normal, they are not in depression, their BS is well controlled...So why? I also read a few reports where people switched the basal insulin from Glargine to Determir (and vice versa too) and the tiredness vanished! This lead me to think that in those having tiredness for no obvious reason, perhaps the response of the body to insulin is the reason. Does the tiredness indicate insufficient calorie intake? If the T1 is taking sufficient calories orally (I won't quibble over the carb/protein/fat ratios) ... then does the tiredness indicate the insufficient uptake of the ingested calories due to a relative deficiency in the action of the basal insulin in this particular person? Remember, insulin is required for the cells to actually be able to metabolize glucose, irrespective of whether the glucose came from carbs, protein or fat. Switching the type of basal insulin would then entail a different drug response and perhaps better relative efficacy.... This would explain why some people cured their tiredness by switching the insulin. Another way might be to increase the dose of insulin to make more calories 'available' to the body. But that would lead to dipping BS, which would have to be offset by increasing the intake of carbs/ protein/fat... I chose carbs as it was the easiest way to explain without getting into the nitty gritty of gluconeogenesis! Like I said, only a theory... I was just trying to figure out why an apparently perfectly treated T1 with no other identifiable comorbidity should feel tired for years. Peace! [emoji255] [/QUOTE]
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