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Message: <blockquote data-quote="Oldvatr" data-source="post: 2581842" data-attributes="member: 196898">Here is a study for T2D.  It is a mouse study, and the way they induce metabolic dysfunction in mice is to overfeed them with a high fat diet and kill off their beta cells with a powerful chemotherapy drug normally used to kill off cancer tumours.  It does produce an effect similar to diabetes, but is not diabetes so may be a weakness in the study.[URL unfurl="true"]https://www.frontiersin.org/articles/10.3389/fcimb.2019.00455/full[/URL]Be aware that mice have two sources of insulin producing  tissue and do not have a single pancreas like humans.  If they clobber one source with directed injection, then the other source may well take over and compensate.</blockquote>

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