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Could someone clear up how reversible insulin resistance is?
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<blockquote data-quote="Brunneria" data-source="post: 1946835" data-attributes="member: 41816"><p>Going back to the original question, insulin resistance can vary quite a lot (depending on things like exercise, medication, carb intake, other hormones, etc.</p><p></p><p>Then you get other stuff involved too</p><p></p><p>For instance, your ability to release insulin depends on how much insulin you usually need. Production ramps up and down, depending in recent requirements. This means that the lower carb you go the more out of practice you are at releasing enough to deal with a higher carb intake. It can take a few days for production to ramp back up if carbs are increased, resulting in a few very high spikes till insulin production increases again.</p><p></p><p>Both the spikes and the increased insulin will also cause insulin resistance to rise too. Since it is excessive exposure to insulin that causes insulin resistance.</p><p></p><p>Then there is beta cell death. Or they may be being smothered by a fatty liver. It is the beta cells which produce insulin. So if they are worn out and die, you won’t get their function back. If they were ‘smothered’ in fat and you remove that fat, then they <em><strong>may</strong></em> start to function again. Depends on several factors. Beta cell regeneration has been observed in young mice. Is it going to happen in the average adult/middle aged/elderly human? VERY unlikely although some people try and trigger it with fasting.</p><p></p><p>Probably fair to say that once you have had high levels of insulin resistance, then you will always have some degree of glucose dysfunction and a tendency towards insulin resistance. However, exercise and avoiding circs that drive insulin resistance back up should keep things ticking along at a lower insulin resistance level.</p><p></p><p>Hope that helps.</p></blockquote><p></p>
[QUOTE="Brunneria, post: 1946835, member: 41816"] Going back to the original question, insulin resistance can vary quite a lot (depending on things like exercise, medication, carb intake, other hormones, etc. Then you get other stuff involved too For instance, your ability to release insulin depends on how much insulin you usually need. Production ramps up and down, depending in recent requirements. This means that the lower carb you go the more out of practice you are at releasing enough to deal with a higher carb intake. It can take a few days for production to ramp back up if carbs are increased, resulting in a few very high spikes till insulin production increases again. Both the spikes and the increased insulin will also cause insulin resistance to rise too. Since it is excessive exposure to insulin that causes insulin resistance. Then there is beta cell death. Or they may be being smothered by a fatty liver. It is the beta cells which produce insulin. So if they are worn out and die, you won’t get their function back. If they were ‘smothered’ in fat and you remove that fat, then they [I][B]may[/B][/I] start to function again. Depends on several factors. Beta cell regeneration has been observed in young mice. Is it going to happen in the average adult/middle aged/elderly human? VERY unlikely although some people try and trigger it with fasting. Probably fair to say that once you have had high levels of insulin resistance, then you will always have some degree of glucose dysfunction and a tendency towards insulin resistance. However, exercise and avoiding circs that drive insulin resistance back up should keep things ticking along at a lower insulin resistance level. Hope that helps. [/QUOTE]
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