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<blockquote data-quote="ert" data-source="post: 2415939" data-attributes="member: 504712"><p>The 3 years to insulin with a c-peptide below 0.2 nmol/l (6 years for LADA with above 0.2 nmol/l readings but below the normal range) figures came from my specialist treating me for type 1 diabetes on diagnosis at the Churchill OCDEM Oxford.</p><p></p><p>There is a reference to the same process for time to insulin for type 2 (relevant to the question asked) diabetics that follow the same timeline once their c-peptide ends up as low after 10 of more years with type 2 diabetes:</p><p></p><p>Time to insulin treatment may also be associated with c-peptide response [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446389/#CR40" target="_blank">40</a>]. In a retrospective study of insulin-treated individuals with T2DM, time to insulin prescription in individuals with an MMTT c-peptide of at most 0.2 nmol/l (suggesting absolute insulin deficiency) was 2.5 (1.5–3) years compared to 6 (3–10.75) years for those with a mixed meal stimulated c-peptide of greater than 0.2 nmol/l (<em>p</em> = 0.005).</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446389/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446389/</a></p></blockquote><p></p>
[QUOTE="ert, post: 2415939, member: 504712"] The 3 years to insulin with a c-peptide below 0.2 nmol/l (6 years for LADA with above 0.2 nmol/l readings but below the normal range) figures came from my specialist treating me for type 1 diabetes on diagnosis at the Churchill OCDEM Oxford. There is a reference to the same process for time to insulin for type 2 (relevant to the question asked) diabetics that follow the same timeline once their c-peptide ends up as low after 10 of more years with type 2 diabetes: Time to insulin treatment may also be associated with c-peptide response [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446389/#CR40']40[/URL]]. In a retrospective study of insulin-treated individuals with T2DM, time to insulin prescription in individuals with an MMTT c-peptide of at most 0.2 nmol/l (suggesting absolute insulin deficiency) was 2.5 (1.5–3) years compared to 6 (3–10.75) years for those with a mixed meal stimulated c-peptide of greater than 0.2 nmol/l ([I]p[/I] = 0.005). [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446389/[/URL] [/QUOTE]
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