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Message: <blockquote data-quote="HairySmurf" data-source="post: 2681237" data-attributes="member: 583820">Just updating this thread in case my post about gliclazide as a test confuses anyone who comes upon it.I had an appointment with my endocrinologist today and I asked him what the purpose of putting me me on gliclazide for a week was.  It wasn't any kind of rough test for T1 - there was a medical purpose.  I gathered that pushing down my blood glucose with gliclazide reduces levels of glucose toxicity that pancreatic beta cells are exposed to.  Basically it seems that lower BG levels, as close to normal as possible, helps a dysfunctional pancreas recover a little, increasing the chances that the Metformin and Dapagliflozin combination (Xigduo) would be sufficient to keep my BG levels down after that point.  I assume that the purpose of testing my BG twice per day and reporting those numbers to the nurse before starting the Xigduo was to verify that the job had been done, that the dose of gliclazide was sufficient to produce a week of near-normal BG levels, and possibly to decide whether Xigduo would be enough medication to go on with at that time.It's probable that the only reason he explained that to me in any detail was I had just asked him about glucose toxicity in the context of T2 remission.  My last HbA1c in January was 39 mmol/mol, while on the Xigduo, down from 89 mmol/mol last October.  There's no way that particular medication could do that by itself and I'm eating 150 to 160g of carbs per day so it looks like my weight loss is having a big effect; that my dysfunctional beta cells are recovering.  He offered me Trulicity or Ozempic, if I wanted it, despite my low HbA1c.  I asked if taking Ozempic along with the Xigduo would help dysfunctional beta cells recover faster by keeping BG control as tight as possible and thereby reducing levels of glucose toxicity.  He thought about it for a second and said there are no guidelines on this.  I was hoping for a little more than that - some guidance on the best way to transition from meds to remission after losing a load of weight.  He said that as I'm experiencing no side effects I should keep taking the Xigduo, that the decision about Trulicity or Ozempic was up to me, and that the only reason he'd recommend taking it on top of the Xigduo would be to help with weight loss and help in maintaining a lower weight.  I chose to stick with the Xigduo, at least until my next appointment (likely in six months) and refused the Ozempic.  No technical remission for me any time soon. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite5" alt=":confused:" title="Confused    :confused:" loading="lazy" data-shortname=":confused:" /></blockquote>

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