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Type 1 Diabetes
Dapagliflozin
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<blockquote data-quote="Oldvatr" data-source="post: 2428370" data-attributes="member: 196898"><p>The FDA in the USA does not allow the use of this drug with T1D, but NICE apparently does in the UK.</p><p><a href="https://www.nice.org.uk/guidance/ta597/chapter/1-Recommendations" target="_blank">https://www.nice.org.uk/guidance/ta597/chapter/1-Recommendations</a></p><p></p><p>Note that the risk of DKA is significantly higher for T1D, and it can occur at any bgl level above 10 mmol/l but still be below 20 mmol/l which is where the usual insulin-deficient DKA is diagnosed in A&E. Make sure A&E staff are made aware that you are taking this medication if needing assistance.</p><p></p><p>Note that incorrect or missed doses of insulin can make matters worse. Best to not take Dapagliflozin near bedtime.</p><p></p><p>Keep well hydrated since this medication increases your fluid excretions, and be especially aware if also taking a water tablet such as furosemide. Observe sick day guidance if necessary.</p><p></p><p>Edit to add: I note you are a pump user. One of my T1D friends suffers blockages in the cannula, and kinks in the tubes that stop the flow of insulin without informing him. Also mis-siting the canula can be problematic. These send him to A*E quite regularly, and the Forxiga could make this worse by speeding up the DKA.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2428370, member: 196898"] The FDA in the USA does not allow the use of this drug with T1D, but NICE apparently does in the UK. [URL]https://www.nice.org.uk/guidance/ta597/chapter/1-Recommendations[/URL] Note that the risk of DKA is significantly higher for T1D, and it can occur at any bgl level above 10 mmol/l but still be below 20 mmol/l which is where the usual insulin-deficient DKA is diagnosed in A&E. Make sure A&E staff are made aware that you are taking this medication if needing assistance. Note that incorrect or missed doses of insulin can make matters worse. Best to not take Dapagliflozin near bedtime. Keep well hydrated since this medication increases your fluid excretions, and be especially aware if also taking a water tablet such as furosemide. Observe sick day guidance if necessary. Edit to add: I note you are a pump user. One of my T1D friends suffers blockages in the cannula, and kinks in the tubes that stop the flow of insulin without informing him. Also mis-siting the canula can be problematic. These send him to A*E quite regularly, and the Forxiga could make this worse by speeding up the DKA. [/QUOTE]
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