Diabetes Reversal breakthrough

Looks interesting. More than I initially thought when I saw 'Daily Mail' and 'mice.'

Hope for type 1s and some help for type 2s, but not sure how it helps insulin resistance. I don't need more insulin. I need improved insulin receptors

Geoff

librarising said:

I don't need more insulin. I need improved insulin receptors

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That's interesting geoff - do you know that through tests? I always assume my issue is not producing enough insulin as I'm not overweight, (I realise this isn't the only cause of resistance), but I don't know this as a fact.

Sounds interesting although It was stated that the mice used in the trial did not have a normally functioning immune system and as I tested positive for GAD Antibodies,I doubt this could be of any help to me personally BUT if a way of protecting the implanted cells from the bodies own immune system was found then I could see how this could be useful for a type 2 patient whose own insulin production is nearing the end of it's life.
It would then obviously depend again on how insulin resistant the patient was.

Grazer said:

librarising said:

I don't need more insulin. I need improved insulin receptors

Click to expand...

That's interesting geoff - do you know that through tests? I always assume my issue is not producing enough insulin as I'm not overweight, (I realise this isn't the only cause of resistance), but I don't know this as a fact.

Click to expand...

When I was diagnosed {another skinny] I was old that I was still producing insulin - and had probably been producing excess insulin for years o compensate for the fact hat my body could no process it properly. As I aged it was no longer able to do this
-or to do it consistently.

This was not based on any tests - I was diagnosed by blood test in he hosptal and later by HBA1C. I was too traumaised by the
manner of my diagnosis and too shocked o ask further questions- in fact it is only now , 5 years on i am reallly sarting to hink about the causes in depth. I have been too busy trying to control it.

I have always had a gut feeling that insulin would not help at all -or at leas while I am sill able to conrol he condition by other means.

I too, would be very interesed o hear if you know of any tess which might confirm your comments Geoff. Thanks.

Grazer wrote
That's interesting geoff - do you know that through tests? I always assume my issue is not producing enough insulin as I'm not overweight, (I realise this isn't the only cause of resistance), but I don't know this as a fact.

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Unbeliever wrote
I too, would be very interesed o hear if you know of any tess which might confirm your comments Geoff. Thanks.

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My GP on diagnosis said I probably had metabolic syndrome, since other markers were also present : hypertension, poor cholesterol figures/ratios, microalbuminaria, and the words insulin resistance were used. And I've had a slow burning sub-clinical hypothyroidism which remains untreated since it's at 'normal' levels. Thyroid antibodies ? Book an appointment when they're killing you. I'm the GP and I know best ! (those are my words translated from my GP's indifference.)

I've found this interesting article, which I shall look at later, (when less busy) :

http://edrv.endojournals.org/content/19/4/477.full

However I quickly note

"What fraction of NIDDM (Geoff = non insulin-dependant diabetes mellitus) is insulin resistant? As mentioned, abundant data document the presence of resistance to insulin action in the majority of NIDDM patients ... it is safe to state that, insofar as they have neither MODY nor LADA, lean NIDDM patients are frequently, but by no means invariably, insulin resistant."

Geoff

Thanks for that Geoff.

These mice must be really healthy so many times we hear of breakthroughs treating them and that's the last we hear of it :sick:

SouthernGeneral6512 said:

These mice must be really healthy so many times we hear of breakthroughs treating them and that's the last we hear of it :sick:

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Not after having the pancreas removed surely? We owe the poor little things a great ddeal.


Yes thanks for the info LIbra rising - much appreciated!