Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Ask A Question
Diabetes type 1 or 2?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="Oldvatr" data-source="post: 2508280" data-attributes="member: 196898"><p>If you research Gliclazide and pancreas burnout, you will find that there is no link between them. The medication does not thrash the pancreas like its predecessors. </p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310990/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310990/</a></p><p></p><p>I did some recent research into c peptide and insulin, and some recent studies have found that the amount of insulin needed is proportional to surface volume of the body. So obese individuals produce and require more insulin. This in turn affects the c peptide test, and the research shows that this is one aspect that leads to wrong diagnosis in that TOFI get dx'ed T1D earlier than weightier cousins simply because they narturally produce less insulin. It is the main reason why losing weight seems to improve insulin sensitivity. The ND diet results show that over the 8 weeks of the study, the ones that lost the most weight had the best improvement in insulin response in the IGTT tests. </p><p></p><p>It does not help you solve your connundrum though. I too have been on max Metformin and Max Gliclazide and also on Actos at the same time as having humingous and horrendous glucose levels. In my case I went LCHF and dropped about 8 stone in about 3 months, and I managed to give up most of my medications. But I am TOFI and got back to what I weighed when at Uni. But it surprised me that diet could achieve that improvement whereas max meds did nowt for me. I am currently on 40 mg of Glic and no Metformin, and my last HbA1c was 45. </p><p></p><p>Although I did go keto in the early days of LCHF, I found I lost too much weight, so I turned it up a bit and now I run above my fat burning threshold. You say you are not losing weight. Well it sounds counter intuitive, but I found increasing fat helped me lose weight. Sounds ridiculous, but actually it has been shown that eating fat does not make you fat.</p><p></p><p>Your fasting (AM) reading seem ok, but something is causing the levels to rise during the day. Now there must be a source for that glucose. Either your liver is emptying (liver dump) but that normally happens when you wake, not during the day. Or your liver is synthesizing glucose out of protein i,e, scavenging, which would be noticeable by muscle weakness and weight loss. I suspect liver dump. It does take a while to discharge the liver storage, and glucose does not appear out of thin air, IF is often suggested for resetting the metabolism, but I believe it works best if you vary the times and duration of the fasts. If IF is regular and predictable, your body gets used to it and compensates.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2508280, member: 196898"] If you research Gliclazide and pancreas burnout, you will find that there is no link between them. The medication does not thrash the pancreas like its predecessors. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310990/[/URL] I did some recent research into c peptide and insulin, and some recent studies have found that the amount of insulin needed is proportional to surface volume of the body. So obese individuals produce and require more insulin. This in turn affects the c peptide test, and the research shows that this is one aspect that leads to wrong diagnosis in that TOFI get dx'ed T1D earlier than weightier cousins simply because they narturally produce less insulin. It is the main reason why losing weight seems to improve insulin sensitivity. The ND diet results show that over the 8 weeks of the study, the ones that lost the most weight had the best improvement in insulin response in the IGTT tests. It does not help you solve your connundrum though. I too have been on max Metformin and Max Gliclazide and also on Actos at the same time as having humingous and horrendous glucose levels. In my case I went LCHF and dropped about 8 stone in about 3 months, and I managed to give up most of my medications. But I am TOFI and got back to what I weighed when at Uni. But it surprised me that diet could achieve that improvement whereas max meds did nowt for me. I am currently on 40 mg of Glic and no Metformin, and my last HbA1c was 45. Although I did go keto in the early days of LCHF, I found I lost too much weight, so I turned it up a bit and now I run above my fat burning threshold. You say you are not losing weight. Well it sounds counter intuitive, but I found increasing fat helped me lose weight. Sounds ridiculous, but actually it has been shown that eating fat does not make you fat. Your fasting (AM) reading seem ok, but something is causing the levels to rise during the day. Now there must be a source for that glucose. Either your liver is emptying (liver dump) but that normally happens when you wake, not during the day. Or your liver is synthesizing glucose out of protein i,e, scavenging, which would be noticeable by muscle weakness and weight loss. I suspect liver dump. It does take a while to discharge the liver storage, and glucose does not appear out of thin air, IF is often suggested for resetting the metabolism, but I believe it works best if you vary the times and duration of the fasts. If IF is regular and predictable, your body gets used to it and compensates. [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Ask A Question
Diabetes type 1 or 2?
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…