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Do Doctors Take Genetic Tests Seriously?
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<blockquote data-quote="PreferredPronoun" data-source="post: 1782451" data-attributes="member: 469836"><p>Hello, there is a service called Promethease where people can upload their raw DNA data from 23andme, etc. It will connect it with a database of research studies and identify possible risks.</p><p></p><p>I have been having various kinds of symptoms such as failing OGTT but being antibody negative for type 1. Here is a research study <a href="https://www.researchgate.net/figure/HLA-analysis-was-performed-in-3402-of-3708-of-the-patients-in-the-Better-Diabetes_fig2_289065369" target="_blank">https://www.researchgate.net/figure/HLA-analysis-was-performed-in-3402-of-3708-of-the-patients-in-the-Better-Diabetes_fig2_289065369</a></p><p></p><p>It spells out that people with HLA-DQ2/DQ8 are incredibly common among antibody negative type 1s. I only have HLA-DQ8 (<a href="https://www.snpedia.com/index.php/Rs7454108" target="_blank">https://www.snpedia.com/index.php/Rs7454108</a>) which is 30% frequency in whites population. This would imply that people with it are at high risk, yet less than 1% of population has issues with glucose.</p><p></p><p>I am just wondering if there are open-minded doctors, willing to look beyond standard diagnostic methods. I was tested for ICA, IA-2 and GAD only though, so 2 other possibilities are not tested.</p></blockquote><p></p>
[QUOTE="PreferredPronoun, post: 1782451, member: 469836"] Hello, there is a service called Promethease where people can upload their raw DNA data from 23andme, etc. It will connect it with a database of research studies and identify possible risks. I have been having various kinds of symptoms such as failing OGTT but being antibody negative for type 1. Here is a research study [URL]https://www.researchgate.net/figure/HLA-analysis-was-performed-in-3402-of-3708-of-the-patients-in-the-Better-Diabetes_fig2_289065369[/URL] It spells out that people with HLA-DQ2/DQ8 are incredibly common among antibody negative type 1s. I only have HLA-DQ8 ([URL]https://www.snpedia.com/index.php/Rs7454108[/URL]) which is 30% frequency in whites population. This would imply that people with it are at high risk, yet less than 1% of population has issues with glucose. I am just wondering if there are open-minded doctors, willing to look beyond standard diagnostic methods. I was tested for ICA, IA-2 and GAD only though, so 2 other possibilities are not tested. [/QUOTE]
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