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Do Doctors Take Genetic Tests Seriously?
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<blockquote data-quote="phoenix" data-source="post: 1782711" data-attributes="member: 12578"><p>I agree that that <em>HLA-DR3-DQ2</em> or <em>HLA-DR4-DQ8 </em> confer a susceptibility to T1 (.The SNP rs7454108 has been used as a marker for DQ8 in several studies, this is one of the alleles tested in the chip used by 23 and me. )</p><p></p><p>This has been known for many years and there are countless papers referring to it. ( including a recent paper suggesting that a drug which supresses the product of DQ8 could prevent T 1 in those susceptible ; hypothesis not yet tested!).<a href="https://jdrf.org.uk/news/blood-pressure-drug-tested-clinical-trial-prevent-type-1-diabetes/" target="_blank">https://jdrf.org.uk/news/blood-pressure-drug-tested-clinical-trial-prevent-type-1-diabetes/</a></p><p>I doubt however that doctors will find it useful to investigate the presence or absence of the haplogroup in a clinical setting.Even with the higher risk ( i.e. carrying both DR3 DQ2 and DR4 DQ8 ) it carries only a 5% risk unless they already have a T1 sibling with the same haplotype .<a href="https://www.diapedia.org/type-1-diabetes-mellitus/21040851211/genetics-of-type-1-diabetes" target="_blank">https://www.diapedia.org/type-1-diabetes-mellitus/21040851211/genetics-of-type-1-diabetes</a>. There are other genes that may play a part and several possible enviromental triggers.</p><p></p><p></p><p>( from a personal point of view, I am also heterozygous for DQ8, [CT] I developed T1 at 52 , I did have GAD antibodies. My father from whom I inherited the T allele was also CT. He lived to age 86 with no glucose problems)</p><p>Edited typo</p></blockquote><p></p>
[QUOTE="phoenix, post: 1782711, member: 12578"] I agree that that [I]HLA-DR3-DQ2[/I] or [I]HLA-DR4-DQ8 [/I] confer a susceptibility to T1 (.The SNP rs7454108 has been used as a marker for DQ8 in several studies, this is one of the alleles tested in the chip used by 23 and me. ) This has been known for many years and there are countless papers referring to it. ( including a recent paper suggesting that a drug which supresses the product of DQ8 could prevent T 1 in those susceptible ; hypothesis not yet tested!).[URL]https://jdrf.org.uk/news/blood-pressure-drug-tested-clinical-trial-prevent-type-1-diabetes/[/URL] I doubt however that doctors will find it useful to investigate the presence or absence of the haplogroup in a clinical setting.Even with the higher risk ( i.e. carrying both DR3 DQ2 and DR4 DQ8 ) it carries only a 5% risk unless they already have a T1 sibling with the same haplotype .[URL]https://www.diapedia.org/type-1-diabetes-mellitus/21040851211/genetics-of-type-1-diabetes[/URL]. There are other genes that may play a part and several possible enviromental triggers. ( from a personal point of view, I am also heterozygous for DQ8, [CT] I developed T1 at 52 , I did have GAD antibodies. My father from whom I inherited the T allele was also CT. He lived to age 86 with no glucose problems) Edited typo [/QUOTE]
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