Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Type 1 Diabetes
Doctor suggestion on Lantus insulin
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="SimonCrox" data-source="post: 1426448" data-attributes="member: 388174"><p>Why do Indo-Asian folk get more diabetes? A good question.</p><p></p><p>It is clear from data, that Indo-Asian folk get T2DM when less obese and younger than Europid folk.</p><p></p><p>See <a href="http://onlinelibrary.wiley.com/doi/10.1111/dom.12915/full" target="_blank">http://onlinelibrary.wiley.com/doi/10.1111/dom.12915/full</a></p><p></p><p>It has been suggested that the increased prevalence is due to lifestyle, sugary diet, lack of exercise, and obesity. But the above shows that they get diabetes more easily and the westernisation of lifestyle just makes it worse.</p><p></p><p>I have always been struck by the sugar content of Indian sweets, pure sugar! But I doubt that poorer folk could afford these; some studies eg in Nederlands have shown that a high sugar diet increases risk of diabetes, even with same BMI.</p><p></p><p>One study looked at middle aged folk in rural India, and on testing (cos 30 – 50% T2DM undiagnosed) 3% had diabetes despite being skinny and working on the fields – this is a high rate of diabetes.</p><p></p><p>Cannot find the paper, but the following summarises:-</p><p></p><p><a href="http://journals.sagepub.com/doi/abs/10.1177/14746514070070010301" target="_blank">http://journals.sagepub.com/doi/abs/10.1177/14746514070070010301</a></p><p></p><p>Some proposed the “Thrifty Genotype” theory which is in populations at risk of starvation, skinny folk do not survive, and the fatter ones survive episodes of starvation to breed and maintain their genes; this tendency to be energy efficient and fat is believed to make one more susceptible to diabetes (I have always felt this is a bit of an unsupported leap). Also, in Europe, we also had starvation; after the Black Death, there were not the folk to work the fields so there was no food, and people were not unduly upset to get press ganged into the Navy, cos they got “a square meal per day” (hence the origin of the English phrase).</p><p></p><p><a href="https://en.wikipedia.org/wiki/Thrifty_gene_hypothesis" target="_blank">https://en.wikipedia.org/wiki/Thrifty_gene_hypothesis</a></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723682/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723682/</a></p><p></p><p>Others (Barker and Hales) were also not convinced and developed the thrifty phenotype hypothesis which is that if one is starved in utero as a foetus before being born, then one adapts to this, and this programming makes one more prone to diabetes, and cardiovascular disease. </p><p></p><p>Folk seem to favour this idea, and the data is clear; if one is born underweight and then gets overweight, one has a greatly increased risk of heart attack, stroke etc. But again, with modern life, maternal under nutrition will hopefully be less common; we have had Indo-Asian families in UK for decades, but their “children” – adults and parents themselves now, still have a very high prevalence of diabetes. So I am not totally convinced this is the answer – I think the phenomenon exists cos of good data, but am not sure it explains fully why so much diabetes in Indo-Asian people.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390698/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390698/</a></p><p></p><p><a href="https://en.wikipedia.org/wiki/Thrifty_phenotype" target="_blank">https://en.wikipedia.org/wiki/Thrifty_phenotype</a></p><p></p><p></p><p></p><p>We know that relatives of Indo-Asian diabetic folk who do not have diabetes themselves, have insulin resistance (the start of T2DM), at a much greater rate than white Europeans. So something is happening to cause this, whether it be genetic or environmental.</p><p></p><p>At the end of the day, I suspect that it is a lot of bad luck giving the Indo-Asian population genes that confer high risk of T2DM, plus the thrifty phenotype and then they just cannot cope with a western lifestyle. The “Bad Luck Theory” has never been proposed before. The Finns have a lot of T1DM, cos of the bad luck to be a small population with an above average number of genes for T1DM (known as “The Founder Effect”).</p><p></p><p>Perhaps, you could ask your diabetes doctors and see what they think? Would be interested to know.</p><p></p><p>Best wishes</p></blockquote><p></p>
[QUOTE="SimonCrox, post: 1426448, member: 388174"] Why do Indo-Asian folk get more diabetes? A good question. It is clear from data, that Indo-Asian folk get T2DM when less obese and younger than Europid folk. See [URL]http://onlinelibrary.wiley.com/doi/10.1111/dom.12915/full[/URL] It has been suggested that the increased prevalence is due to lifestyle, sugary diet, lack of exercise, and obesity. But the above shows that they get diabetes more easily and the westernisation of lifestyle just makes it worse. I have always been struck by the sugar content of Indian sweets, pure sugar! But I doubt that poorer folk could afford these; some studies eg in Nederlands have shown that a high sugar diet increases risk of diabetes, even with same BMI. One study looked at middle aged folk in rural India, and on testing (cos 30 – 50% T2DM undiagnosed) 3% had diabetes despite being skinny and working on the fields – this is a high rate of diabetes. Cannot find the paper, but the following summarises:- [URL]http://journals.sagepub.com/doi/abs/10.1177/14746514070070010301[/URL] Some proposed the “Thrifty Genotype” theory which is in populations at risk of starvation, skinny folk do not survive, and the fatter ones survive episodes of starvation to breed and maintain their genes; this tendency to be energy efficient and fat is believed to make one more susceptible to diabetes (I have always felt this is a bit of an unsupported leap). Also, in Europe, we also had starvation; after the Black Death, there were not the folk to work the fields so there was no food, and people were not unduly upset to get press ganged into the Navy, cos they got “a square meal per day” (hence the origin of the English phrase). [URL]https://en.wikipedia.org/wiki/Thrifty_gene_hypothesis[/URL] [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723682/[/URL] Others (Barker and Hales) were also not convinced and developed the thrifty phenotype hypothesis which is that if one is starved in utero as a foetus before being born, then one adapts to this, and this programming makes one more prone to diabetes, and cardiovascular disease. Folk seem to favour this idea, and the data is clear; if one is born underweight and then gets overweight, one has a greatly increased risk of heart attack, stroke etc. But again, with modern life, maternal under nutrition will hopefully be less common; we have had Indo-Asian families in UK for decades, but their “children” – adults and parents themselves now, still have a very high prevalence of diabetes. So I am not totally convinced this is the answer – I think the phenomenon exists cos of good data, but am not sure it explains fully why so much diabetes in Indo-Asian people. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390698/[/URL] [URL]https://en.wikipedia.org/wiki/Thrifty_phenotype[/URL] We know that relatives of Indo-Asian diabetic folk who do not have diabetes themselves, have insulin resistance (the start of T2DM), at a much greater rate than white Europeans. So something is happening to cause this, whether it be genetic or environmental. At the end of the day, I suspect that it is a lot of bad luck giving the Indo-Asian population genes that confer high risk of T2DM, plus the thrifty phenotype and then they just cannot cope with a western lifestyle. The “Bad Luck Theory” has never been proposed before. The Finns have a lot of T1DM, cos of the bad luck to be a small population with an above average number of genes for T1DM (known as “The Founder Effect”). Perhaps, you could ask your diabetes doctors and see what they think? Would be interested to know. Best wishes [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Type 1 Diabetes
Doctor suggestion on Lantus insulin
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…