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Type 1 Diabetes
Does active preservation of the honeymoon period improve lifetime prognosis?
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<blockquote data-quote="MarkMunday" data-source="post: 2283247" data-attributes="member: 525839"><p>This is an epidemiological study, so it doesn't jump to conclusions. But the logical connections are clear. The study found that many of the 50+ year complication free medalists still had active beta cells. They produce both c-peptide and insulin. It goes almost without saying that destruction of beta cells to shorten the honeymoon and precludes this outcome - having active beta cells after 50+ years of T1 duration. That having these beta cells improves control and the long term complication outcome is more tenuous, but it would not be surprising. Conversely, preserving beta cells, which also keeps the 'honeymoon' going as long as possible, improves the long-term prognosis.</p><p></p><p>If we accept that poor control causes complications and residual beta cell function makes control easier, the long-term case of preserving beta cells is compelling. The researchers did not jump to this conclusion as they are still looking for other possible protective factors, like genetics. There are no-doubt other factors that affect long-term T1 outcomes. But as diabetics, we can only work with things we can control. Like diet, exercise and insulin regimen. Preservation of beta cells is something recently diagnosed T1s can do, and the indications are that it will make life easier for them down the road. This is why I urge newly diagnosed T1s to make the most of this opportunity. Yes, I could be wrong and it turns out preserving beta cells doesn't help. But is that a risk worth taking?</p><p></p><p>And, BTW, everything everyone writes on an online forum is opinion. If asked for an explanation, I give it. Much of what your doctor tells you is also just opinion. Ultimately, you need to do your own research and reach your own conclusions. I really don't mind if people don't agree with me, as long as their arguments are sound. Saying that you don't agree with something because it doesn't come from a peer reviewed published article doesn't tell me much about your interpretation and objection.</p></blockquote><p></p>
[QUOTE="MarkMunday, post: 2283247, member: 525839"] This is an epidemiological study, so it doesn't jump to conclusions. But the logical connections are clear. The study found that many of the 50+ year complication free medalists still had active beta cells. They produce both c-peptide and insulin. It goes almost without saying that destruction of beta cells to shorten the honeymoon and precludes this outcome - having active beta cells after 50+ years of T1 duration. That having these beta cells improves control and the long term complication outcome is more tenuous, but it would not be surprising. Conversely, preserving beta cells, which also keeps the 'honeymoon' going as long as possible, improves the long-term prognosis. If we accept that poor control causes complications and residual beta cell function makes control easier, the long-term case of preserving beta cells is compelling. The researchers did not jump to this conclusion as they are still looking for other possible protective factors, like genetics. There are no-doubt other factors that affect long-term T1 outcomes. But as diabetics, we can only work with things we can control. Like diet, exercise and insulin regimen. Preservation of beta cells is something recently diagnosed T1s can do, and the indications are that it will make life easier for them down the road. This is why I urge newly diagnosed T1s to make the most of this opportunity. Yes, I could be wrong and it turns out preserving beta cells doesn't help. But is that a risk worth taking? And, BTW, everything everyone writes on an online forum is opinion. If asked for an explanation, I give it. Much of what your doctor tells you is also just opinion. Ultimately, you need to do your own research and reach your own conclusions. I really don't mind if people don't agree with me, as long as their arguments are sound. Saying that you don't agree with something because it doesn't come from a peer reviewed published article doesn't tell me much about your interpretation and objection. [/QUOTE]
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