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Dr. Malcom Kendrick On Saturated Fat
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<blockquote data-quote="Oldvatr" data-source="post: 1830611" data-attributes="member: 196898"><p>To add to the problem, Dr Kendrick is correct that dietary fat is packaged into chylomicrons in the blood by the intestines, so a high fat diet will increase this particle in the blood, so there will be an increase in triglycerides in the blood within the chylomicrons. This fat is used by muscles in the body as controlled by the lipase enzyme. The chylomicrons get filtered out by the liver mainly by conversion into LDL for either storage or use in the bloodstream. So increased dietary fat will increase LDL eventually according to this alternate hypothesis. Fasting and keto diets and DP will all affect the amount of LDL released by the liver but this is not necessarily linked to mealtimes per se, so Kendrick is correct in that there is no direct link between fat intake to raising LDL, but it is still affected in the long term</p><p></p><p>The LDL that is deemed to be harmful to us is not the LDL produced by the liver, but is the remnants from LDL as it gets used up. The HDL normally hoovers this up for disposal or reuse in the liver, but there is a percentage that gets damaged, and which HDL cannot bind to. This is called LDL-C and is also referred to as small dense LDL or sLDL. This is the nasty stuff that we need to reduce if we can. Recent studies seem to show that a low carb higher fat diet creates larger fluffier LDL particles that are good, and reduces the LDL-C stuff A ketogenic diet also claims to burn up more LDL than a non keto diet and there are studies that seem to back this up. There are also other studies that show one can reduce LDL too low such that it becomes harmful to us and leads apparently to a reduced lifespan. </p><p></p><p>I think that if Kendrick had said that LDL-C is not cholesterol, then again he would be wrong, since LDL-C is mostly cholesterol that cannot be re-used or removed easily by the body, and so forms plaque. which is why furred up arteries are known to be blocked by cholesterol - true. But the source of that cholesterol is not directly related to food intake - it is self made by our own bodies not eggs or shellfish we eat. Smoking, radiation, pesticides'pollutants etc all damage LDL to cause LDL-C</p><p></p><p>There is also a worry that the chylomicron remnants also contribute to small particles that are as harmful as LDL-C, so the chylomicrons are not necessarily safe. When they are good, they are very very good, but when they go bad they are also horrid.</p><p></p><p>Adding to this confusion, the lab tests used to measure LDL do not actually do that. the LDL figure is a mathematical calculation that estimates LDL from the HDL and trig values, and the formula assumes that the trig/ cholesterol ratio remains constant, which in practice it does not. So LDL figure that the doc tells you is bad is a rough guess into what is going on and not really a strong measure at all.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1830611, member: 196898"] To add to the problem, Dr Kendrick is correct that dietary fat is packaged into chylomicrons in the blood by the intestines, so a high fat diet will increase this particle in the blood, so there will be an increase in triglycerides in the blood within the chylomicrons. This fat is used by muscles in the body as controlled by the lipase enzyme. The chylomicrons get filtered out by the liver mainly by conversion into LDL for either storage or use in the bloodstream. So increased dietary fat will increase LDL eventually according to this alternate hypothesis. Fasting and keto diets and DP will all affect the amount of LDL released by the liver but this is not necessarily linked to mealtimes per se, so Kendrick is correct in that there is no direct link between fat intake to raising LDL, but it is still affected in the long term The LDL that is deemed to be harmful to us is not the LDL produced by the liver, but is the remnants from LDL as it gets used up. The HDL normally hoovers this up for disposal or reuse in the liver, but there is a percentage that gets damaged, and which HDL cannot bind to. This is called LDL-C and is also referred to as small dense LDL or sLDL. This is the nasty stuff that we need to reduce if we can. Recent studies seem to show that a low carb higher fat diet creates larger fluffier LDL particles that are good, and reduces the LDL-C stuff A ketogenic diet also claims to burn up more LDL than a non keto diet and there are studies that seem to back this up. There are also other studies that show one can reduce LDL too low such that it becomes harmful to us and leads apparently to a reduced lifespan. I think that if Kendrick had said that LDL-C is not cholesterol, then again he would be wrong, since LDL-C is mostly cholesterol that cannot be re-used or removed easily by the body, and so forms plaque. which is why furred up arteries are known to be blocked by cholesterol - true. But the source of that cholesterol is not directly related to food intake - it is self made by our own bodies not eggs or shellfish we eat. Smoking, radiation, pesticides'pollutants etc all damage LDL to cause LDL-C There is also a worry that the chylomicron remnants also contribute to small particles that are as harmful as LDL-C, so the chylomicrons are not necessarily safe. When they are good, they are very very good, but when they go bad they are also horrid. Adding to this confusion, the lab tests used to measure LDL do not actually do that. the LDL figure is a mathematical calculation that estimates LDL from the HDL and trig values, and the formula assumes that the trig/ cholesterol ratio remains constant, which in practice it does not. So LDL figure that the doc tells you is bad is a rough guess into what is going on and not really a strong measure at all. [/QUOTE]
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