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Drug Cocktail

majortom

Member
Messages
8
Location
Shrewsbury
Dislikes
Drugs!
Hi Folks
I'm a newbie to this site although have lived with Type 2 for over 8 years. Have tried diet control for a few years (and failed), now on Metformin SR 2 x 500 twice daily, Glixclazide 1 x 80mg once daily plus blood pressure tabs and statins. HbA1c in August 9.5 so diabetic nurse referred me to diabetic consultant. He has put me on Sitagliptin (yet to be prescribed and taken) and also suggested I up my dose of Gliclazide to 2 x 80 daily to help with hypo's.

On reading the mountain of extremely valuable info' on this site I haven't come across anyone mentioning that they take metformin, gliclazide AND sitagliptin. The latter always seems to be a substitute for gliclazide. Is anyone else on a similar cocktail? :?
 
Hi Tom and welcome to the forum I'm afraid I can't help you with information about your cocktail of drugs as I don't take all of them - only Metformin, blood pressure tabs and statins, but if there are any members who take that combination, or some of those drugs, I hope they will answer you soon when they see your post. You could have a look at this forum where you will find information about each individual medication.

viewforum.php?f=26

I know you have had diabetes for 8 years but we give out this information to all new members and I hope you will find it both interesting and helpful. Hopefully this will help you to lower your levels. Ask as many other questions as you like as you are sure to get an answer.

 
Hi Tom, I don't take gliciazide but I do have glimepiride which is from tne same clss of drugs as well as metformin and sitagliptin,
I have been taking sitagliptin for over a year and within a short time I was able to reduce my glimepiride. In fact I stopped taking it altogether and would like to have continued that way
but asked to be put back on the minimum dose {1mg} purely because I have HBA1Cs every few months which,unfortunately, means some contact with the Diabetes nuse in my practice.

As I have responsibility for a couple of people wih mental health issues my routine may often be disrupted and althiough my levels {HBA1C} are now about 6 I know the slightest rise would be attributed to "natural progresssion " of the disease as she is dying to put me on insulin!

You may well find that once the sitagliptin {good for spikes} kicks in,
you may be able to leave off the gliciazide.

I know what you mean about the "cocktail". I think that the longer you have been T2 the more likely you are to have been prescribed a coctail. They try something new but are then afraid to remove the tried and tested drug.

Good luck wih the sitaglyptin I have found it very effective.
 
Hi

I am on the same drug regime i.e. Met, Glic and Sitagliptin. All three drugs have a different approach to managing BS so each can help. I have found that Glic doesn't have much effect for me whereas Sitagliptin does. Glic stimulates the Pancreas to create more insulin whereas Sitagliptin suppresses a DPP-4 enzyme that in turn suppresses insulin production. I'm inclined to agree that taking Glic and Sitagliptin may not be ncessary depending on the exact type of DB you have. I have in fact reduced my Glic by 1 tablet and may take even less. You mention upping the Glic to reduce hypos? Surely the reverse applies. Glic can induce hypos in some people and you will see warnings on the web. This is unlikely if Sitagliptin has been added by your GP as, by definition, Glic has failed to work adequately in producing enough insulin?
 
Hi tom
I'm also on a cocktail of drugs,i have type2 for over 8 years now and i take metformin 850mg 3 times a day,verapamil,ramipril,simvastatin.I also take warfarin because i keep geting blood clots. I was taken glixclazide 3 times a day but was taken of that and i now take insulin novorapid 3 times a day and levemir at night. I have found i can control my diabetes alot better since i came off glixclazide and insulin give me better control of my bg.
I wish you well with your cocktail and hope all goes well for you.
Mike
 
Hi All
Many thanks for the speedy and informative replies to my post - the one thing that prompted me to join the community and post a query after living with D for 8 years was the level of support and assistance the community gives each other on coping with the illness.

I have not focussed on managing my condition as much as I should have done over previous years, hence my gradual slide - I was even offered insulin at the consultant appointment I had recently, but want to stay off injections for as long as possible.

My problem is that I am now trying to do too much at once, after years of negelect, being far too stoic with my diet and taking tablets religiously. I'm also testing my BS far more regulalry to get an understanding of the effectc of medication and diet - something which I have never taken seriously. (Having a family that tells me that my new found focus is a tad OCD doesn't help!).

Daibell, I stand corrected re my oringinal post, my HbA1C and spikes of over 10mmol/L on fasting being the reason for upping the Glic - the hypo's have just got worse since doubling the dose but I'm now monitoring what I eat and when I take the tablets to level out my BS.

Many, many thanks for these replies once agian, I shall bore eveyone with Sitagliptin effects when and if!
Glenn
 
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