Effective treatment for complications not coming to a chemist near you...

Yes, it really is maddening. I have had several recent conversations with my consultant about the role of evidence when it comes to analysing diabetes control.

In computing, we can't keep full logging on all the time on systems because it uses too much system resource and impacts performance, so we decide on an appropriate logging level for each system in normal operation, but the first thing we do when anything starts to go wrong is turn on full logging so that we gather evidence to analyse to try to root cause the issue.

In diabetes management we take a guess at what might be wrong, followed by a guess at how we might fix it. Not my idea of good problem-solving techniques and certainly not evidence-based.

As for c-peptide, I've long believed it must have a role to play in our bodies - otherwise it wouldn't be produced. It's very disappointing that so much is known about its impact, but so little movement seems to be made to produce a replacement form of it. Having said that, I would have thought that Type 2s do still produce c-peptide, so there should be a significant difference in the complications associated with Type 1 and Type 2 if it plays a considerable role in the avoidance of complications. Or maybe that's too simplistic.

Smidge

I seem to recall hearing an interview with a Joslin medalist called Richard who said he never had complications until he was put on modern insulin and he also put it down to the lack of c-peptide. I'll see if I can track it down and post it for you if you like?

Is it still in animal insulins?

I've recenbtly had a C-Peptide test. The result was 18!!!

That's high - but I still don't know what that means...

Indy51 said:

I seem to recall hearing an interview with a Joslin medalist called Richard who said he never had complications until he was put on modern insulin and he also put it down to the lack of c-peptide. I'll see if I can track it down and post it for you if you like?

Is it still in animal insulins?

Click to expand...

I am sure that I read a while back that is was purified out of animal insulins

Patch said:

I've recenbtly had a C-Peptide test. The result was 18!!!

That's high - but I still don't know what that means...

Click to expand...

At a guess it sounds like your body is making lot's of it's own insulin but you're just very resistant to it.

If anyone's interested, here's the interview link: http://www.tudiabetes.org/forum/topics/live-interview-with-tom-and-richard-ask-an-old-timer

Request for information forwarded to Drug Safety and Information
Department, Wockhardt UK Limited (incorporating CP Pharmaceuticals Limited
and The Wallis Laboratory Limited)
Enquiry: Received: 07.06.2010
Response date: 07.06.2010
*
Wockhardt UK Limited's Hypurin Insulins are highly purified. The complex
processing removes any traces of C-peptide that may be present to extremely
low levels.*

from:
http://www.tudiabetes.org/forum/topics/porcupine-insulin-in-canada-you-can-get-some-too

robert72 said:

Wockhardt UK Limited's Hypurin Insulins are highly purified. The complex
processing removes any traces of C-peptide that may be present to extremely
low levels.*

Click to expand...

But present nonetheless Rob. When researchers were studying the Joslin 50 (who were complication free) it was found that they were still producing small amount of insulin despite their longevity ....thus still producing C-peptide, obviously it was in small quantities but possibly enough to prevent long-term complications they think.

Podcast here:
http://www.alliesvoice.com/2013/01/16/c-peptide-the-oasis-in-the-diabetes-desert/

There is a bit about T2 , C peptide and complications

The trouble with these small companies is that they don't have the capital to develop their ideas past initial trials.
There is also this one which has the same researcher at the helm http://www.creativepeptides.se/science.html
But it's not just small pharma, how about DUK ?

phoenix said:

The trouble with these small companies is that they don't have the capital to develop their ideas past initial trials.
There is also this one which has the same researcher at the helm http://www.creativepeptides.se/science.html
But it's not just small pharma, how about DUK ?

Click to expand...

In the podcast it said that creative peptides moved from Sweden to California to become cebix

Blame my OH for talking in that bit!

Fascinating stuff. I guarantee that the big pharma companies will be on to this. There is plenty of profit to be made from this.

Indy51 said:

I seem to recall hearing an interview with a Joslin medalist called Richard who said he never had complications until he was put on modern insulin and he also put it down to the lack of c-peptide. I'll see if I can track it down and post it for you if you like?

Is it still in animal insulins?

Click to expand...

As an aside Richard is a very lovely gentleman and has also written a book about his 65+ years of living with type 1 which is well worth a read. He is a genuinely nice chap and very modest about how well he has done over the years, when you think about how diabetes was treated when he was first diagnosed compared to in the last few years it really does show that there are probably a host of other things going on that determine who gets complications and who doesn't.

He also posts at another UK forum and has quite a long blog about his experiences at that forum. Very modest man and still trying to help as many newly diagnosed children and their parents as he can.

Guys - seeing as my C-Peptide is currently at 18, would you expect a Diabetic Specialist to suggest/prescribe a Basal & Bolus Insulin Regime???

Patch said:

Guys - seeing as my C-Peptide is currently at 18, would you expect a Diabetic Specialist to suggest/prescribe a Basal & Bolus Insulin Regime???

Click to expand...

What was your most recent HbA1c level like Patch?