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<blockquote data-quote="Biggles2" data-source="post: 1628594" data-attributes="member: 406880"><p>This is 2016 guidance is from the European Medicines Agency (I'm not sure if this guidance has been adopted by NICE):</p><p></p><p style="margin-left: 20px">Up to now, metformin medicines were not recommended for patients with moderate to severe</p> <p style="margin-left: 20px">reduction of kidney function. This recommendation has now changed to allow their use in patients</p> <p style="margin-left: 20px">with moderately reduced kidney function (GFR=30–59 ml/min). The dose of metformin should be</p> <p style="margin-left: 20px">adapted depending on the patient’s kidney function. These medicines should still not be used in</p> <p style="margin-left: 20px">patients with severely reduced kidney function (GFR less than 30 ml/min).</p><p></p><p><a href="http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2016/10/WC500214248.pdf" target="_blank">http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2016/10/WC500214248.pdf</a></p></blockquote><p></p>
[QUOTE="Biggles2, post: 1628594, member: 406880"] This is 2016 guidance is from the European Medicines Agency (I'm not sure if this guidance has been adopted by NICE): [INDENT]Up to now, metformin medicines were not recommended for patients with moderate to severe reduction of kidney function. This recommendation has now changed to allow their use in patients with moderately reduced kidney function (GFR=30–59 ml/min). The dose of metformin should be adapted depending on the patient’s kidney function. These medicines should still not be used in patients with severely reduced kidney function (GFR less than 30 ml/min).[/INDENT] [URL]http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2016/10/WC500214248.pdf[/URL] [/QUOTE]
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