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Eledon - an insulin injection free life?

urbanracer

urbanracer

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Folks I cannot find Eledon in response to a forum search so I hope I am duplicating information here.
This is something that I recently came across via social media and have since looked at other information sources. It seems to be valid.
Katie Beth Hand is patient #9 on the Eledon Trial and she is now living without insulin injections in what appears to be a novel approach to immuno suppressant drugs.
She is sharing lots of information via Facebook videos, Instagram and Youtube. so if you search for her on-line you will find some really interesting stuff.
Kinda looks promising.
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CheeseSeaker said:
A step forward potentially, but not a cure.

100% Insulin Independence: Why Eledon’s Breakthrough is a Pillar, Not a Cure | Diabettech - Diabetes and Technology

Eledon Pharmaceuticals recently achieved 100% insulin independence in an early-phase islet transplant trial using its anti-CD40L drug, tegoprubart. It’s a massive step forward in transplant immunology that avoids the toxicity of standard drugs. But why isn't it a cure yet, and how does it fit...
www.diabettech.com www.diabettech.com
Click to expand...
I was thinking this.. I was reading about similar stuff in the new scientist 4 decades ago?
 
I think the difference is that in previous trials/patients they had to take immunosuppressant drugs for the rest of their lives, whereas this trial has a drug given once beside the islet cells.
 
Hopeful34 said:
I think the difference is that in previous trials/patients they had to take immunosuppressant drugs for the rest of their lives, whereas this trial has a drug given once beside the islet cells.
Click to expand...
Yes - its less invasive (fewer side effects) but couldn't be rolled out as a cure - but does show more promise than the 4 decades old solution @Jaylee remembers (though very similar lines).

Ultimately its interesting but unlikely to be a cure all for us - for a good bit of time and development at least.
 
Hopeful34 said:
I think the difference is that in previous trials/patients they had to take immunosuppressant drugs for the rest of their lives, whereas this trial has a drug given once beside the islet cells.
Click to expand...

That's not what I took from a report on a different patient who was said to be "on a immunosuppression regimen" and had taken tegoprubart for the whole of the 18 months since the procedure (and I assume she would have to continue to take it for the rest of her life).

Difference seems to be that this immunosuppression drug does not appear to have the extremely serious side-effects that the others have.
 
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