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Type 2 Diabetes
Exercising down a high reading
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<blockquote data-quote="phoenix" data-source="post: 269629" data-attributes="member: 12578"><p>Exercise works because it is far easier for glucose to get into the cell during exercise. At rest insulin is needed for glucose to get into the cell During exercise more glucose is needed and there is a secondary system that enables glucose to get into the cells and doesn't require insulin. </p><p></p><p><strong> Sciency Bit</strong></p><p> Glucose gets into cells via glucose transporters (GLUT) .</p><p> GLUT 4 is the transporter found in muscle and skeletal cells. This transporter is brought to the surface of the cell by insulin </p><p> In people with T2 with insulin resistance this 'translocation' may be impaired.</p><p> <strong>GLUT 4 can also be activated by muscle contraction and this part of the system works fine in people with diabetes</strong>.</p><p>This means that during exercise glucose is able cross the cell wall ie out of the blood stream and into the muscle where it is needed without insulin.</p><p>(In people without insulin resistance these two systems are additive; this can be the case in T1 which is why injected insulin + exercise can result in a very rapid drop in glucose levels)</p><p> The Insulin signalling system which controls the 'glucostat' also seems to work more normally in T2s during exercise ( the enzyme that controls this (AMPK) is also activated by metformin)</p><p> very sciency link</p><p><a href="http://outreach.mcb.harvard.edu/downloads/Fall09/LaurieGoodyear.pdf" target="_blank">http://outreach.mcb.harvard.edu/downloa ... odyear.pdf</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 269629, member: 12578"] Exercise works because it is far easier for glucose to get into the cell during exercise. At rest insulin is needed for glucose to get into the cell During exercise more glucose is needed and there is a secondary system that enables glucose to get into the cells and doesn't require insulin. [b] Sciency Bit[/b] Glucose gets into cells via glucose transporters (GLUT) . GLUT 4 is the transporter found in muscle and skeletal cells. This transporter is brought to the surface of the cell by insulin In people with T2 with insulin resistance this 'translocation' may be impaired. [b]GLUT 4 can also be activated by muscle contraction and this part of the system works fine in people with diabetes[/b]. This means that during exercise glucose is able cross the cell wall ie out of the blood stream and into the muscle where it is needed without insulin. (In people without insulin resistance these two systems are additive; this can be the case in T1 which is why injected insulin + exercise can result in a very rapid drop in glucose levels) The Insulin signalling system which controls the 'glucostat' also seems to work more normally in T2s during exercise ( the enzyme that controls this (AMPK) is also activated by metformin) very sciency link [url=http://outreach.mcb.harvard.edu/downloads/Fall09/LaurieGoodyear.pdf]http://outreach.mcb.harvard.edu/downloa ... odyear.pdf[/url] [/QUOTE]
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