Metabolism_Boss
Well-Known Member
- Messages
- 170
- Location
- High Wycombe
- Type of diabetes
- Type 2
- Treatment type
- Tablets (oral)
- Dislikes
- Reality TV shows. Celebrities that are famous for being famous
It has been known for a long time that we have a 24 hour rhythm of activity for almost all our hormones, brain chemistry, digestive enzymes and heart activity. They are programmed to peak and trough in activity at the optimal time within the 24 hours. This circadian rhythm is controlled by circadian clocks, which are present in every organ.
An interesting article in The Scientist has relevance to diabetics, as it discusses how circadian muscle regulation may have an effect on how glucose is getting into muscle fibres (or not).
https://www.the-scientist.com/features/muscle-clocks-play-a-role-in-regulating-metabolism-64705
This work has shown that the circadian rhythm has a major effect on carbohydrate metabolism in muscle tissue. Interfering with this rhythm in mice led to disrupted glucose metabolism, leading to obesity and metabolic syndrome. Further interference with other genes that are involved with controlling the circadian rhythm led to glucose intolerance and abnormalities in gluconeogenesis. This appears to be due to the disruption of the sensitivity to insulin in that phase of the rhythm where the mice are active and feeding. The muscle tissue was not able to efficiently transport glucose into the muscle in the presence of insulin. This was found to be due to the reduction in transport proteins on the cell wall and the reduced activity of an enzyme inside the muscle cell that metabolises glucose.
An interesting article in The Scientist has relevance to diabetics, as it discusses how circadian muscle regulation may have an effect on how glucose is getting into muscle fibres (or not).
https://www.the-scientist.com/features/muscle-clocks-play-a-role-in-regulating-metabolism-64705
This work has shown that the circadian rhythm has a major effect on carbohydrate metabolism in muscle tissue. Interfering with this rhythm in mice led to disrupted glucose metabolism, leading to obesity and metabolic syndrome. Further interference with other genes that are involved with controlling the circadian rhythm led to glucose intolerance and abnormalities in gluconeogenesis. This appears to be due to the disruption of the sensitivity to insulin in that phase of the rhythm where the mice are active and feeding. The muscle tissue was not able to efficiently transport glucose into the muscle in the presence of insulin. This was found to be due to the reduction in transport proteins on the cell wall and the reduced activity of an enzyme inside the muscle cell that metabolises glucose.