Hello I totally empathise with you....I have like you gone through many tests but constipation became worse regardless of trying flax,psyillium husks lactulose,etc etc... I know how you feel not wanting to eat or drink.....I eventually had a colonoscopy which discovered my left traverse colon is kinked,hence no matter what I used it didn't solve the problem.....I am now now on a medication called laxido ,it is cumulative so helps things move through. The gastroenterologist said no matter how much fruit (I personally can't digest fibre) it won't work because the colon is too twisted to make for smooth passage. As you have tried many things perhaps it's time to consult a gastroenterologist to check your colon. Hope this gives some help..........