I use my frilo bags camping with no access to fridge or cool box, It has keep insulin supplies for 2 diabetics, and we've never found any problem with keeping it this way, the only difference with tempreture is that the hotter the climate is, the quicker the frilo pouch needs reactivating to maintain it's cooling ability.. Mind you the first time you activate when it's completely dried, it seems to take ages, but once you'll up and runing a reasonble length dunk in water does the trick..