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Type 2 Diabetes
Glibenclamide
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<blockquote data-quote="TorqPenderloin" data-source="post: 1130507" data-attributes="member: 211504"><p>I'm amazed that Glibenclamide is still legal to be used.</p><p></p><p>If you do your research on it, it's the single most cited sulfonylurea that leads to cell apoptosis. In layman's terms that means there a ton of evidence to suggest that it can lead to your son's pancreas no longer producing insulin.</p><p></p><p>If we were talking about someone who was 70 years old, it might not be a huge deal as life expectancy is a factor at that point. However, if it were my kid (or me) I would NEVER even consider it.</p><p></p><p>The weight gain associated with the drug is essentially no different from the Lantus he's already taking. Most people with type 2 are put on a sulfonylurea BEFORE artificial insulin which is why he's hearing about the weight gain side-effects.</p><p></p><p>Is he making other adjustments in his life/lifestyle to control his type 2 diabetes? I'm not going to make any assumptions but diet and exercise are extremely important for ANYONE and certainly people with diabetes (of all types).</p></blockquote><p></p>
[QUOTE="TorqPenderloin, post: 1130507, member: 211504"] I'm amazed that Glibenclamide is still legal to be used. If you do your research on it, it's the single most cited sulfonylurea that leads to cell apoptosis. In layman's terms that means there a ton of evidence to suggest that it can lead to your son's pancreas no longer producing insulin. If we were talking about someone who was 70 years old, it might not be a huge deal as life expectancy is a factor at that point. However, if it were my kid (or me) I would NEVER even consider it. The weight gain associated with the drug is essentially no different from the Lantus he's already taking. Most people with type 2 are put on a sulfonylurea BEFORE artificial insulin which is why he's hearing about the weight gain side-effects. Is he making other adjustments in his life/lifestyle to control his type 2 diabetes? I'm not going to make any assumptions but diet and exercise are extremely important for ANYONE and certainly people with diabetes (of all types). [/QUOTE]
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