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Message: <blockquote data-quote="Oldvatr" data-source="post: 1795593" data-attributes="member: 196898">That is an interesting report, and very relevant to this discussion,  One thing that stands out in my mind is that one problem noted with the sulfonylurea therapy is that it was difficult to get good metabolic control in any of the RCT trials.  This harks back to the early days with the stage 1 sulfanyls that a were not very effective anyway, and secondly were not as good as exogenous insulin for bgl control.  So given that beta cells are damaged by high levels of glucose, then their findings are not so surprising.  Indeed the particular drug used in the RCT trials is known to be not as effective as Metformin. However there does seem to be an adverse effect on the autoimmune problem that is particular to LADA.The other problem that the RCT trials do not consider is that the standard advice for diabetics has been (and remains) Eat lots of carbs, especially starchy foods, and reduce fats.  So it is not surprising that the insulin therapy was more successful when compared to the oral drug being used.  It remains to be seen what would happen if these tests were repeated now with a suitable lifestyle change (i,e, LC diet) also in place.  Unfortunately that will not happen in the immediate future and is irrelevant to today's discussion.</blockquote>

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