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Sulphonylureas & Prandial Glucose Regulators
Gliclazide and Heart Failure
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<blockquote data-quote="Oldvatr" data-source="post: 2014840" data-attributes="member: 196898"><p>I was on Glic for over 3 years, and was successfully controlling my bgl, with an HbA1c of 42 last year. Then last month I had a blue light visit to A&E for a couple of heart attacks. I survived those, and am now waiting for surgery to improve my outlook. However, during the episodes, my bgl rocketed up into the stratosphere (32+) and my diabetic meds were stopped by the consultant. When I returned back to nearer the ground, I was told my Glic was possibly responsible for my heart failure, and that the drug is contraindicated from now on for me. I am having to get by on metformin and not much else seeing as I am still having to eat hospital food. They will not re-instate my Glic and are saying that the only drug I can take with my dicky ticker is an SGLT-2 Inhibitor, which I have immediately refused due to its reported side effects being unacceptable for me.</p><p></p><p>I have tried to find out why my consultant has banned Glic from my future, and all I can find is a small study report in the AHA Journal that shows a weak association (0.35% increase in CVE) for those taking Glic alone, but no significant risk if Glic is taken with Metformin which is what I was taking before the excitement began. Does anyone have any info on this contraindication, since it is something that is not so far in the prescribing guidelines that I can see (NICE, BNF etc)so we may need to raise this as a new warning.</p><p></p><p><span style="color: #0000ff">Edit to add: The Consultant who stopped my meds did it because I no longer need it. He confirms there is no contraindication or association between Gliclazide and heart failure currently in place, and that if I find I need something in future, then I can ask my GP. Studies I have posted in this thread show that Glic may have a protective effect for CVE and may help reduce mortality.</span></p><p><span style="color: #0000ff"></span></p><p><span style="color: #0000ff">I have answered my own question, Thank you.</span></p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2014840, member: 196898"] I was on Glic for over 3 years, and was successfully controlling my bgl, with an HbA1c of 42 last year. Then last month I had a blue light visit to A&E for a couple of heart attacks. I survived those, and am now waiting for surgery to improve my outlook. However, during the episodes, my bgl rocketed up into the stratosphere (32+) and my diabetic meds were stopped by the consultant. When I returned back to nearer the ground, I was told my Glic was possibly responsible for my heart failure, and that the drug is contraindicated from now on for me. I am having to get by on metformin and not much else seeing as I am still having to eat hospital food. They will not re-instate my Glic and are saying that the only drug I can take with my dicky ticker is an SGLT-2 Inhibitor, which I have immediately refused due to its reported side effects being unacceptable for me. I have tried to find out why my consultant has banned Glic from my future, and all I can find is a small study report in the AHA Journal that shows a weak association (0.35% increase in CVE) for those taking Glic alone, but no significant risk if Glic is taken with Metformin which is what I was taking before the excitement began. Does anyone have any info on this contraindication, since it is something that is not so far in the prescribing guidelines that I can see (NICE, BNF etc)so we may need to raise this as a new warning. [COLOR=#0000ff]Edit to add: The Consultant who stopped my meds did it because I no longer need it. He confirms there is no contraindication or association between Gliclazide and heart failure currently in place, and that if I find I need something in future, then I can ask my GP. Studies I have posted in this thread show that Glic may have a protective effect for CVE and may help reduce mortality. I have answered my own question, Thank you.[/COLOR] [/QUOTE]
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