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<blockquote data-quote="SimonCrox" data-source="post: 2078170" data-attributes="member: 388174"><p>Hi</p><p>As others have said, this is pioglitazone 15 mg ie low dose</p><p>In PROACTIVE trial, this decreased the rate of heart attack and stroke in folk who had previously had these. It probably decreases the incidence of dementia, and probably improves fatty liver. It does not cause hypoglycaemia and can be used with very poor renal function. In ADOPT rosiglitazone controlled glucose levels longer than metformin or sulphonylurea,</p><p></p><p>The bad points are that it can cause fluid retention, so keep looking at the ankles, and can cause dramatic weight gain. It can also cause anaemia via several mechanisms and has a slight risk of a peripheral fracture, so make sure adewuate vitamin D in diet (tablets/capsules) or sunshine ie guess. The risk of bladder cancer is uncertain and so if there is an increased risk, the increase in risk is very small.</p><p></p><p>I think that it was the bladder cancer that made the french ban Pio; although a francophile, I would not totally trust their judgement and I wonder if they are influenced by others- for instance they continued to use Mercator (made by a French company) for several years after other countries banned it with several deaths and much morbidity from the stuff.</p><p></p><p>We are not allowed to recomend treatment here; I seem to recall that pio is one of the NICE frontline drugs because it is generic and hence cheap. And there are good reasons to use it. It sounds as if weight is not a problem, which is a little unusual for someone with T2DM</p><p></p><p>The other member of the class, rosiglitazone, was withdrawn when it was shown to increase the risk of heart attack, stroke etc by Steve Nissen. althogh has been re-introduced follwoing the findings of no increased risk in RECORD. Troglitazone was banned when 1 in 60,000 americans developed liver failure and died on it. But there is now a lot of experience with pio since it has been around since at least 2000, so there should not be any unpleasant surprises from the stuff.</p><p></p><p>best wishes</p></blockquote><p></p>
[QUOTE="SimonCrox, post: 2078170, member: 388174"] Hi As others have said, this is pioglitazone 15 mg ie low dose In PROACTIVE trial, this decreased the rate of heart attack and stroke in folk who had previously had these. It probably decreases the incidence of dementia, and probably improves fatty liver. It does not cause hypoglycaemia and can be used with very poor renal function. In ADOPT rosiglitazone controlled glucose levels longer than metformin or sulphonylurea, The bad points are that it can cause fluid retention, so keep looking at the ankles, and can cause dramatic weight gain. It can also cause anaemia via several mechanisms and has a slight risk of a peripheral fracture, so make sure adewuate vitamin D in diet (tablets/capsules) or sunshine ie guess. The risk of bladder cancer is uncertain and so if there is an increased risk, the increase in risk is very small. I think that it was the bladder cancer that made the french ban Pio; although a francophile, I would not totally trust their judgement and I wonder if they are influenced by others- for instance they continued to use Mercator (made by a French company) for several years after other countries banned it with several deaths and much morbidity from the stuff. We are not allowed to recomend treatment here; I seem to recall that pio is one of the NICE frontline drugs because it is generic and hence cheap. And there are good reasons to use it. It sounds as if weight is not a problem, which is a little unusual for someone with T2DM The other member of the class, rosiglitazone, was withdrawn when it was shown to increase the risk of heart attack, stroke etc by Steve Nissen. althogh has been re-introduced follwoing the findings of no increased risk in RECORD. Troglitazone was banned when 1 in 60,000 americans developed liver failure and died on it. But there is now a lot of experience with pio since it has been around since at least 2000, so there should not be any unpleasant surprises from the stuff. best wishes [/QUOTE]
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