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glitazones

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chris1960

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hi ihave recently changed from rosiglitizone to pioglitizone and dont seem to be getting the same benifits any idea why this is or if there is a better alternative ??

regards chris
 
Hi Chris,
Research last year showed that rosiglitazone can cause heart attacks, whereas pioglitazone is less likely to. I suspect that is why you have been switched.
 
well sort of i went to the doctors because i had found out about it causing heart attacks took them a week to agree to change me over but since then and me giving up smoking i cant seem to control my sugar as well with pio i wondered if there was a better alternative
 
Hi Chris,
I suspect that giving up smoking has a lot to do with your BS problems. I gave up nearly 2 years ago and for several weeks my BS was all over the place. I suspect it is because your body is having to fight nicotine addiction and so is under considerable stress. Stress does play havoc with BS levels.

The glitazone family of meds are designed to reduce insulin resistance so act in a very similar way to metformin but are much more powerful. I've not heard of pio being less potent than rosi (or vice versa). As far as I am aware the only drugs that available that are designed to reduce insulin resistance are Biguanides (metformin/Glucophage) and thiazolidinediones (the glitazones).
 
well thank you for the information dennis much appreciated was really concerned the pioglitazone wasnt doing its job but didnt know if it was me stopping smoking as well when i went to the doctors last week they didnt seem to concerned about it being too high but they never seem to give me much information about anything when i advised them about rosi causing heart attacks they wanted to know where i had got my info from advised them from this site found out more about type 2 from here than my doctors i sometimes wonder :-)
 
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