"Glucophage" is the branded version, containing basic metformin. "Glucophage SR" contains a modified formulation for "modified release", usually called slow release, and can be better for those who react badly to the basic metformin. In my opinion generic forms of the drug are just as good if you can tolerate the "bog-standard" stuff, and they are much cheaper than the branded Glucophage. But if you can't tolerate it, then Glucophage SR is worth a try. I was recently swapped onto this, and was supplied with branded Glucophage SR, but my prescription reads "Metformin MR tabs 500mg" which I assume is a generic description, so there may be a cheaper version of the slow release variant not bearing the expensive Glucophage label. According to my DN the slow release version (4 X 500mg each day) costs the NHS £59 a month more than basic generic Metformin, which is why its not prescribed unless necessary.