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<blockquote data-quote="Yorksman" data-source="post: 413984" data-attributes="member: 55568"><p>It's the liver and pancreatic triglycerides that are important. Taylor's 'twin cycle hypothesis is:</p><p></p><p><em>"The accumulation of fat in liver and secondarily in the pancreas will lead to self-reinforcing cycles that interact to bring about type 2 diabetes. Fatty liver leads to impaired fasting glucose metabolism and increases export of VLDL triacylglycerol, which increases fat delivery to all tissues, including the islets. The liver and pancreas cycles drive onward after diagnosis with steadily decreasing β-cell function."</em></p><p></p><p>Different people put down fat in different places but, you don't know how much you need to put down in your liver to start the diabetes process because that again varies from person to person. Moreover, some people may look slim, but have deposits of fat in these organs setting them on the road to diabetes.</p><p></p><p><em>"Individual tolerance of different degrees of fat exposure vary, and understanding this liposusceptibility will underpin the future understanding of genetically determined risk in any given environment. However, this should not obscure the central point: If a person has type 2 diabetes, there is more fat in the liver and pancreas than he or she can cope with."</em></p></blockquote><p></p>
[QUOTE="Yorksman, post: 413984, member: 55568"] It's the liver and pancreatic triglycerides that are important. Taylor's 'twin cycle hypothesis is: [i]"The accumulation of fat in liver and secondarily in the pancreas will lead to self-reinforcing cycles that interact to bring about type 2 diabetes. Fatty liver leads to impaired fasting glucose metabolism and increases export of VLDL triacylglycerol, which increases fat delivery to all tissues, including the islets. The liver and pancreas cycles drive onward after diagnosis with steadily decreasing β-cell function."[/i] Different people put down fat in different places but, you don't know how much you need to put down in your liver to start the diabetes process because that again varies from person to person. Moreover, some people may look slim, but have deposits of fat in these organs setting them on the road to diabetes. [i]"Individual tolerance of different degrees of fat exposure vary, and understanding this liposusceptibility will underpin the future understanding of genetically determined risk in any given environment. However, this should not obscure the central point: If a person has type 2 diabetes, there is more fat in the liver and pancreas than he or she can cope with."[/i] [/QUOTE]
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