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<blockquote data-quote="Mr_Pot" data-source="post: 1612840" data-attributes="member: 216415"><p><span style="font-family: 'Arial'">We seem to agree that HbA1c has its shortcomings that can make it an inaccurate measure of average blood glucose, in particular the variation between people as to the lifetime of their red blood cells and the greater significance of the most recent weeks before the test. Also a short term high glucose spike could be a source of damage in the body but not be registered by HbA1c so additional means of measuring variation in BG are advisable.</span></p><p><span style="font-family: 'Arial'"></span></p><p><span style="font-family: 'Arial'"></span></p><p><span style="font-family: 'Arial'">As I said in my original post my interest is just “academic” I find it fascinating how the human body works and the more I read, the more I realise how little I know and how complex everything is. I do have some observations about [USER=44622]@Squire Fulwood[/USER] ‘s blog and the post by [USER=6467]@LittleGreyCat[/USER] .</span></p><p><span style="font-family: 'Arial'"></span></p><p><span style="font-family: 'Arial'"></span></p><p><span style="font-family: 'Arial'">Glucose is carried around the body in the blood plasma, the liquid in which the blood cells are suspended not by the cells themselves. As far as I know the glucose “accidentally “gets attached to haemoglobin molecules in the red blood cells. As this attachment has been shown to be proportional to the concentration of glucose in the plasma it can be used as a measure of average blood glucose levels that have existed over the lifetime of a cell. I have not seen any evidence that this attachment only occurs when cells have just been created, I think it just happens randomly during their lifetime.</span></p><p><span style="font-family: 'Arial'"></span></p><p><span style="font-family: 'Arial'"></span></p><p><span style="font-family: 'Arial'">I hadn’t realised until recently the enormous numbers involved…..</span></p><p><span style="font-family: 'Arial'"></span></p><p><span style="font-family: 'Arial'">There are about 5,000,000 red blood cells per cubic mm of blood.</span></p><p><span style="font-family: 'Arial'">If the human body contains 5 Litres of blood then there are about 25,000,000,000,000 RBC in total.</span></p><p><span style="font-family: 'Arial'">If they are replaced every 120 days = 120x24x60x60 seconds </span></p><p><span style="font-family: 'Arial'">Then red blood cells are created at a rate of about 2,400,000 per second.</span></p><p><span style="font-family: 'Arial'">Each red blood cell contains about 270,000,000 haemoglobin molecules.</span></p><p><span style="font-family: 'Arial'">So 648,000,000,000,000 haemoglobin molecules are created <u>every second</u>.</span></p><p><span style="font-family: 'Arial'"></span></p></blockquote><p></p>
[QUOTE="Mr_Pot, post: 1612840, member: 216415"] [FONT=Arial]We seem to agree that HbA1c has its shortcomings that can make it an inaccurate measure of average blood glucose, in particular the variation between people as to the lifetime of their red blood cells and the greater significance of the most recent weeks before the test. Also a short term high glucose spike could be a source of damage in the body but not be registered by HbA1c so additional means of measuring variation in BG are advisable. As I said in my original post my interest is just “academic” I find it fascinating how the human body works and the more I read, the more I realise how little I know and how complex everything is. I do have some observations about [USER=44622]@Squire Fulwood[/USER] ‘s blog and the post by [USER=6467]@LittleGreyCat[/USER] . Glucose is carried around the body in the blood plasma, the liquid in which the blood cells are suspended not by the cells themselves. As far as I know the glucose “accidentally “gets attached to haemoglobin molecules in the red blood cells. As this attachment has been shown to be proportional to the concentration of glucose in the plasma it can be used as a measure of average blood glucose levels that have existed over the lifetime of a cell. I have not seen any evidence that this attachment only occurs when cells have just been created, I think it just happens randomly during their lifetime. I hadn’t realised until recently the enormous numbers involved….. There are about 5,000,000 red blood cells per cubic mm of blood. If the human body contains 5 Litres of blood then there are about 25,000,000,000,000 RBC in total. If they are replaced every 120 days = 120x24x60x60 seconds Then red blood cells are created at a rate of about 2,400,000 per second. Each red blood cell contains about 270,000,000 haemoglobin molecules. So 648,000,000,000,000 haemoglobin molecules are created [U]every second[/U]. [/FONT] [/QUOTE]
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