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<blockquote data-quote="Fleegle" data-source="post: 1730000" data-attributes="member: 402985"><p>Hi all. Trying to tap into the collective brain of this forum.</p><p></p><p>Since being diabetic I have been trying to research how HBA1C works and I can find two types of papers on it - one of which talks very high level - it is an average of your blood glucose over 12 weeks by measuring glucose signatures in the haemoglobin - and the second type talks in such detail of biology and chemistry I can not decipher them!</p><p></p><p>This is what I have concluded so far and I wondered whether people had seen documented evidence to support or deny. </p><p>BTW - I understand the problems with people who's blood cells do not last as long as 12 weeks or hang around longer - this is about the how this all is designed to work if you were Josephine average.</p><p></p><p>- Blood cells are created all of the time and last, on average 12 weeks.</p><p>- At time of creation - the cell picks up the current glucose level ???. (I cannot see how in its life the cell could work out average!)</p><p>or - how does that work?</p><p>- This does not change during its life. </p><p>- Once in the lab the blood cells are analysed and from that set they take an average.</p><p></p><p>If this is true do you think that there is also a figure for low and high - that would be interesting to see to wouldn't it? </p><p></p><p>I could very well have drawn the wrong conclusions so if you have read differently or my interpretation is wrong please do correct me.</p></blockquote><p></p>
[QUOTE="Fleegle, post: 1730000, member: 402985"] Hi all. Trying to tap into the collective brain of this forum. Since being diabetic I have been trying to research how HBA1C works and I can find two types of papers on it - one of which talks very high level - it is an average of your blood glucose over 12 weeks by measuring glucose signatures in the haemoglobin - and the second type talks in such detail of biology and chemistry I can not decipher them! This is what I have concluded so far and I wondered whether people had seen documented evidence to support or deny. BTW - I understand the problems with people who's blood cells do not last as long as 12 weeks or hang around longer - this is about the how this all is designed to work if you were Josephine average. - Blood cells are created all of the time and last, on average 12 weeks. - At time of creation - the cell picks up the current glucose level ???. (I cannot see how in its life the cell could work out average!) or - how does that work? - This does not change during its life. - Once in the lab the blood cells are analysed and from that set they take an average. If this is true do you think that there is also a figure for low and high - that would be interesting to see to wouldn't it? I could very well have drawn the wrong conclusions so if you have read differently or my interpretation is wrong please do correct me. [/QUOTE]
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