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Help: Animal Insulin!!!!!!!!!!!!!!!
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<blockquote data-quote="Riesenburg" data-source="post: 303765" data-attributes="member: 41402"><p>Hi Anna,</p><p></p><p>I use a mix of analog and animal insulins (I know very strange but it works). Like yourself had no end of trouble with the Lantus, later found out that it actually has a greater propensity to cross the blood-brain barrier than other insulins which might explain some of its effects.</p><p></p><p>I'm on humalog for my quick acting one (could not cope with the 30mins -6/8hrs action time of the so called rapid animal ones), and on Hypurin Porcine Isophane (for my basal). The Isophane can be taken either once or twice a day. I personally would suggest looking a the Procine ones first, the main reason is that out of the two they are the most similar to human insulin molecules (there is only 1 carbon different), whereas the Bovine ones have 3 different carbons which would result in faster rejections (your body would be more prone to produce antibodies for the beef ones than the proc ones). As for the Neutrals they take a LONG time to get your sugars down, if you can control when you will eat and match the insulin peeks right it works great but if you have a busy lifestyle and your meal times need to shift even by 45mins it causes problems (besides having to stay high until the insulin finally crashes it down, if you are not too sensitive to highs then it could work).</p><p></p><p>Ultimately, getting hold of them is not a problem since they are produced here in the UK. It takes the pharmacy one day (usually) to get them ordered in. The nice thing about the animal insulins is that they are far more efficient at protein synthesis than the analogues which will reduce general muscular fatigue.</p><p></p><p>If you are going to change do it with the help of an endocrinologist, it can be quite a tricky thing to deal with during the initial shift. Once things stabilize it's great...</p><p></p><p>Hope that helps,</p><p>Frankie</p></blockquote><p></p>
[QUOTE="Riesenburg, post: 303765, member: 41402"] Hi Anna, I use a mix of analog and animal insulins (I know very strange but it works). Like yourself had no end of trouble with the Lantus, later found out that it actually has a greater propensity to cross the blood-brain barrier than other insulins which might explain some of its effects. I'm on humalog for my quick acting one (could not cope with the 30mins -6/8hrs action time of the so called rapid animal ones), and on Hypurin Porcine Isophane (for my basal). The Isophane can be taken either once or twice a day. I personally would suggest looking a the Procine ones first, the main reason is that out of the two they are the most similar to human insulin molecules (there is only 1 carbon different), whereas the Bovine ones have 3 different carbons which would result in faster rejections (your body would be more prone to produce antibodies for the beef ones than the proc ones). As for the Neutrals they take a LONG time to get your sugars down, if you can control when you will eat and match the insulin peeks right it works great but if you have a busy lifestyle and your meal times need to shift even by 45mins it causes problems (besides having to stay high until the insulin finally crashes it down, if you are not too sensitive to highs then it could work). Ultimately, getting hold of them is not a problem since they are produced here in the UK. It takes the pharmacy one day (usually) to get them ordered in. The nice thing about the animal insulins is that they are far more efficient at protein synthesis than the analogues which will reduce general muscular fatigue. If you are going to change do it with the help of an endocrinologist, it can be quite a tricky thing to deal with during the initial shift. Once things stabilize it's great... Hope that helps, Frankie [/QUOTE]
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