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<blockquote data-quote="Winnie53" data-source="post: 916713" data-attributes="member: 160246"><p>I did a brief look around the web this morning for more information on Metformin and B12 deficiency.</p><p></p><p>Excerpt from Chris Kresser's e-book, "B12 Deficiency" - (all of his eBooks are free by joining the ChrisKresser.com community, which is also free)...</p><p></p><p><strong></strong></p><p><strong><em>Treatment of B12 deficiency</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><em>One of the greatest tragedies of the B12 epidemic is that diagnosis and treatment is</em></p><p><em></em></p><p><em></em></p><p><em>relatively easy and cheap – especially when compared to treatment of the diseases B12</em></p><p><em></em></p><p><em></em></p><p><em>deficiency can cause. A B12 test can be performed by any laboratory, and should be</em></p><p><em></em></p><p><em></em></p><p><em>covered by insurance. If you don’t have insurance, you can order it yourself from a lab</em></p><p><em></em></p><p><em></em></p><p><em>like DirectLabs.com for $60.</em></p><p><em></em></p><p><em></em></p><p><em>As always, adequate treatment depends on the underlying mechanism causing the</em></p><p><em></em></p><p><em></em></p><p><em>problem. People with pernicious anemia or inflammatory gut disorders like Crohn’s</em></p><p><em></em></p><p><em></em></p><p><em>disease are likely to have impaired absorption for their entire lives, and will likely require</em></p><p><em></em></p><p><em></em></p><p><em>B12 injections indefinitely. This may also be true for those with severe B12 deficiency</em></p><p><em></em></p><p><em></em></p><p><em>causing neurological symptoms.</em></p><p><em></em></p><p><em></em></p><p><em>Some recent studies have suggested that high dose oral or nasal administration may be</em></p><p><em></em></p><p><em>as effective as injections for those with B12 malabsorption problems. However, most B12</em></p><p><em></em></p><p><em></em></p><p><em>experts still recommend injections for people with pernicious anemia and advanced B12</em></p><p><em></em></p><p><em></em></p><p><em>deficiency involving neurological symptoms.</em></p><p><em></em></p><p><em></em></p><p><em>Cyanocobalamin is the most frequently used form of B12 supplementation in the US. But</em></p><p><em></em></p><p><em></em></p><p><em>recent evidence suggests that hydroxycobalamin (frequently used in Europe) is superior</em></p><p><em></em></p><p><em></em></p><p><em>to cyanocobalamin, and methylcobalamin may be superior to both – especially for</em></p><p><em></em></p><p><em></em></p><p><em>neurological disease.</em></p><p><em></em></p><p><em></em></p><p><em>Japanese studies indicate that methylcobalamin is even more effective in treating the</em></p><p><em></em></p><p><em></em></p><p><em>neurological sequelae of B12 deficiency, and that it may be better absorbed because it</em></p><p><em></em></p><p><em></em></p><p><em>bypasses several potential problems in the B12 absorption cycle. On top of that,</em></p><p><em></em></p><p><em></em></p><p><em>methylcobalamin provides the body with methyl groups that play an role in various</em></p><p><em></em></p><p><em></em></p><p><em>biological processes important to overall health.</em></p><p><em></em></p><p><em></em></p><p><em>chriskresser.com !6</em></p><p><em></em></p><p><em>If you suspect you have B12 deficiency, the first step is to get tested. You need an</em></p><p><em></em></p><p><em></em></p><p><em>accurate baseline to work from. If you are B12 deficient, the next step is to identify the</em></p><p><em></em></p><p><em></em></p><p><em>mechanism causing the deficiency. This is something you’ll probably need help with from</em></p><p><em></em></p><p><em></em></p><p><em>a medical practitioner. Once the mechanism is identified, the appropriate form (injection,</em></p><p><em></em></p><p><em></em></p><p><em>oral, sublingual or nasal) of supplementation, the dose and the length of treatment can</em></p><p><em></em></p><p><em></em></p><p><em>be selected.</em></p><p><em></em></p><p><em></em></p><p><em>So, next time you or someone you know is “having a senior moment”, remember: it might</em></p><p><em></em></p><p><em></em></p><p><em>not be “just aging”. It could be B12 deficiency.</em></p><p></p><p>And here's an interesting study, published in Diabetes Care in 2012 - (it's hard to understand; the tables are what I found most helpful)...</p><p></p><p>Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements</p><p></p><p><a href="http://care.diabetesjournals.org/content/35/2/327.full" target="_blank">http://care.diabetesjournals.org/content/35/2/327.full</a></p></blockquote><p></p>
[QUOTE="Winnie53, post: 916713, member: 160246"] I did a brief look around the web this morning for more information on Metformin and B12 deficiency. Excerpt from Chris Kresser's e-book, "B12 Deficiency" - (all of his eBooks are free by joining the ChrisKresser.com community, which is also free)... [B] [I]Treatment of B12 deficiency[/I] [/B] [I]One of the greatest tragedies of the B12 epidemic is that diagnosis and treatment is relatively easy and cheap – especially when compared to treatment of the diseases B12 deficiency can cause. A B12 test can be performed by any laboratory, and should be covered by insurance. If you don’t have insurance, you can order it yourself from a lab like DirectLabs.com for $60. As always, adequate treatment depends on the underlying mechanism causing the problem. People with pernicious anemia or inflammatory gut disorders like Crohn’s disease are likely to have impaired absorption for their entire lives, and will likely require B12 injections indefinitely. This may also be true for those with severe B12 deficiency causing neurological symptoms. Some recent studies have suggested that high dose oral or nasal administration may be as effective as injections for those with B12 malabsorption problems. However, most B12 experts still recommend injections for people with pernicious anemia and advanced B12 deficiency involving neurological symptoms. Cyanocobalamin is the most frequently used form of B12 supplementation in the US. But recent evidence suggests that hydroxycobalamin (frequently used in Europe) is superior to cyanocobalamin, and methylcobalamin may be superior to both – especially for neurological disease. Japanese studies indicate that methylcobalamin is even more effective in treating the neurological sequelae of B12 deficiency, and that it may be better absorbed because it bypasses several potential problems in the B12 absorption cycle. On top of that, methylcobalamin provides the body with methyl groups that play an role in various biological processes important to overall health. chriskresser.com !6 If you suspect you have B12 deficiency, the first step is to get tested. You need an accurate baseline to work from. If you are B12 deficient, the next step is to identify the mechanism causing the deficiency. This is something you’ll probably need help with from a medical practitioner. Once the mechanism is identified, the appropriate form (injection, oral, sublingual or nasal) of supplementation, the dose and the length of treatment can be selected. So, next time you or someone you know is “having a senior moment”, remember: it might not be “just aging”. It could be B12 deficiency.[/I] And here's an interesting study, published in Diabetes Care in 2012 - (it's hard to understand; the tables are what I found most helpful)... Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements [URL]http://care.diabetesjournals.org/content/35/2/327.full[/URL] [/QUOTE]
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