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How do I weigh up taking a diabetic medication that could cause cancer?
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<blockquote data-quote="Dark Horse" data-source="post: 1697374" data-attributes="member: 52527"><p>This meta-analysis from last year states that "there is no link between long-term use of pioglitazone and bladder cancer" and that "the explanation of hypothetically increased risk of bladder malignancy should be attributed to other factors".</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544610/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544610/</a></p><p></p><p>This systematic literature review and meta-analysis,also from last year, "observed a small but statistically significant association between ever (vs. never) use of pioglitazone and bladder cancer risk; however, causality is not established and one cannot rule out alternative explanations". They went on to say, "Importantly, when studies without adjustment for lifestyle factors were excluded, the effect size was not statistically significant."</p><p><a href="http://www.encepp.eu/encepp/openAttachment/studyResult/18797;jsessionid=TQj267g37Z6km1ADsWESKC_xFVrqaOVJU4oKu6oBv2XA3oQ0l6Lc!298584184" target="_blank">http://www.encepp.eu/encepp/openAttachment/studyResult/18797;jsessionid=TQj267g37Z6km1ADsWESKC_xFVrqaOVJU4oKu6oBv2XA3oQ0l6Lc!298584184</a></p></blockquote><p></p>
[QUOTE="Dark Horse, post: 1697374, member: 52527"] This meta-analysis from last year states that "there is no link between long-term use of pioglitazone and bladder cancer" and that "the explanation of hypothetically increased risk of bladder malignancy should be attributed to other factors". [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544610/[/URL] This systematic literature review and meta-analysis,also from last year, "observed a small but statistically significant association between ever (vs. never) use of pioglitazone and bladder cancer risk; however, causality is not established and one cannot rule out alternative explanations". They went on to say, "Importantly, when studies without adjustment for lifestyle factors were excluded, the effect size was not statistically significant." [URL]http://www.encepp.eu/encepp/openAttachment/studyResult/18797;jsessionid=TQj267g37Z6km1ADsWESKC_xFVrqaOVJU4oKu6oBv2XA3oQ0l6Lc!298584184[/URL] [/QUOTE]
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