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Message: <blockquote data-quote="Oldvatr" data-source="post: 1681214" data-attributes="member: 196898"><p>It is a plausible theory that T2D IR is caused by fat in the muscle cells,  However I am not aware that any scientific research has actually demonstrated this.  One of the problems is that the fat in muscle cells tends to be glucogen, not lipid based (again Krebs Cycle) and it is only recently that the likes of Fung et al  have presented this theory,  This is based on observing the first stage of ketosis where low glucose levels lead to weight loss, primarily glucogen and water, but full keto is where fat burning starts on the lipid fat stores.  It seems that reduction in IR and recovery of metabolism follows serious weight loss either through VLCal or VLCarb i,e, is due to loss of lipid fat, but the assumption that it is muscle fat loss may be premature assumption,  Certainly just losing glucogen weight alone does not seem to reset the system</p></blockquote><p></p>

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