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Message: <blockquote data-quote="Brunneria" data-source="post: 1724337" data-attributes="member: 41816">You may find this interesting<a href="https://www.ncbi.nlm.nih.gov/m/pubmed/28963752/" target="_blank">https://www.ncbi.nlm.nih.gov/m/pubmed/28963752/</a>There is a video on YouTube called ‘Metformin a series of unfortunate events’.It is a rather odd video made during a conference presentation.  On it, the presenter discusses Metformin and explains many of the common misconceptions held by doctors about the drug.  These apparently include misunderstandings about when it should be prescribed, how much, when it shouldn’t be prescribed - and why.I haven’t checked the references used in the vid, but the presenter states that doubling the dose from, say, 1000mg to 2000mg does not double the efficacy, so it becomes an increase of diminishing returns.</blockquote>

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