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Type 1 Diabetes
How long was I diabetic before I was diagnosed?
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<blockquote data-quote="phoenix" data-source="post: 175008" data-attributes="member: 12578"><p>In T2, there may have been detectable problems with a rise in fasting blood glucose thirteen years before the occurance of T2. There are also unfortunately many people who develop it but it goes undiagnosed until complications set in.</p><p><a href="http://www.medicinenet.com/script/main/art.asp?articlekey=101072" target="_blank">http://www.medicinenet.com/script/main/ ... key=101072</a></p><p></p><p>It can also take many years to develop T1, the older the person at diagnosis, the more likely it is to be a slowly developing form. Though adults can also have a rapid onset.</p><p> LADA is a subset of autoimmune T1 .One model suggests that in LADA (latent autoimmune diabetes of adults and also in what some researcher's have called LADY (latent autoimmune diabetes of the young) there is a series of autoimmnune attacks followed by beta cell regeneration (we know this cycle of the production of some new cells followed by cell death and regeneration continues to happen in many long term T1s from the Joslin 50 years trials). Each 'attack' leaves the beta cells at a lower level than before. Eventually there aren't enough beta cells left and the person develops overt diabetes. Sometimes they are diagnosed with sufficient cells remaining to manage with oral medication, but sooner or later they will become insulin dependent. </p><p>This diagram illustrates the model.</p><p>Autoimmune Diabetes Not Requiring Insulin at Diagnosis (Latent Autoimmune Diabetes of the Adult)Definition, characterization, and potential prevention. Paolo Pozzilli, MD1 and Umberto Di Mario, MD<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite8" alt=":D" title="Big Grin :D" loading="lazy" data-shortname=":D" />iabetes Care Aug 2001</p></blockquote><p></p>
[QUOTE="phoenix, post: 175008, member: 12578"] In T2, there may have been detectable problems with a rise in fasting blood glucose thirteen years before the occurance of T2. There are also unfortunately many people who develop it but it goes undiagnosed until complications set in. [url=http://www.medicinenet.com/script/main/art.asp?articlekey=101072]http://www.medicinenet.com/script/main/ ... key=101072[/url] It can also take many years to develop T1, the older the person at diagnosis, the more likely it is to be a slowly developing form. Though adults can also have a rapid onset. LADA is a subset of autoimmune T1 .One model suggests that in LADA (latent autoimmune diabetes of adults and also in what some researcher's have called LADY (latent autoimmune diabetes of the young) there is a series of autoimmnune attacks followed by beta cell regeneration (we know this cycle of the production of some new cells followed by cell death and regeneration continues to happen in many long term T1s from the Joslin 50 years trials). Each 'attack' leaves the beta cells at a lower level than before. Eventually there aren't enough beta cells left and the person develops overt diabetes. Sometimes they are diagnosed with sufficient cells remaining to manage with oral medication, but sooner or later they will become insulin dependent. This diagram illustrates the model. Autoimmune Diabetes Not Requiring Insulin at Diagnosis (Latent Autoimmune Diabetes of the Adult)Definition, characterization, and potential prevention. Paolo Pozzilli, MD1 and Umberto Di Mario, MD:Diabetes Care Aug 2001 [/QUOTE]
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