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Type 1 Diabetes
How Many Hypo's Is Too Many?
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<blockquote data-quote="tim2000s" data-source="post: 1977086" data-attributes="member: 30007"><p>It has a long profile in everyone. People are just mistaken in thinking that it only lasts for 3 hours. Nearly all the fast acting insulin has a half life of around 55 minutes, which means it gets down to practically less than 1% being active in <strong>about 7 hours</strong>. Very few people are really aware how long the tail is and as a result, most people's insulin dosing doesn't account for rapid and long acting insulins correctly. </p><p></p><p></p><p>Agreed, however, short term studies don't clearly tell you what the impact on hypo symptoms are in the long term, which is the real concern about running low levels for long periods, whether cognitively functioning or not. </p><p></p><p></p><p>No. There have been studies in monkeys showing that levels need to get <em><strong>REALLY REALLY </strong></em> low before brain damage occurs. Brain cells and synapses aren't damaged until glucose levels drop down below 1.1 mmols for long periods (5-6 hours).</p></blockquote><p></p>
[QUOTE="tim2000s, post: 1977086, member: 30007"] It has a long profile in everyone. People are just mistaken in thinking that it only lasts for 3 hours. Nearly all the fast acting insulin has a half life of around 55 minutes, which means it gets down to practically less than 1% being active in [B]about 7 hours[/B]. Very few people are really aware how long the tail is and as a result, most people's insulin dosing doesn't account for rapid and long acting insulins correctly. Agreed, however, short term studies don't clearly tell you what the impact on hypo symptoms are in the long term, which is the real concern about running low levels for long periods, whether cognitively functioning or not. No. There have been studies in monkeys showing that levels need to get [I][B]REALLY REALLY [/B][/I] low before brain damage occurs. Brain cells and synapses aren't damaged until glucose levels drop down below 1.1 mmols for long periods (5-6 hours). [/QUOTE]
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How Many Hypo's Is Too Many?
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