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How reliable are HbA1c tests?
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<blockquote data-quote="ziggy_w" data-source="post: 2224739" data-attributes="member: 323454"><p>Hi [USER=518059]@Lupf[/USER],</p><p></p><p>I've done some research into the topic and yes, HbA1c does not always reflect actual blood sugar levels for individuals. In fact, it can be off quite signficantly. Below is a graphic from the following article, which compares average glucose levels using CGM in mg/dl (divide by 18 to get mmol) and HbA1c: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521971/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521971/</a></p><p></p><p><img src="https://www.ncbi.nlm.nih.gov/corecgi/tileshop/tileshop.fcgi?p=PMC3&id=108437&s=70&r=1&c=1" alt="" class="fr-fic fr-dii fr-draggable " style="" /></p><p></p><p>Based on this chart, for an HbA1c of 6.3%, for example, average blood glucose readings based on CGM can range from about 110 mg/dl to about 180 mg/dl.</p><p></p><p>Another set of researchers found that HbA1c is out by 7.2 mmol in 40% of individuals. Here's the link to this article: <a href="https://academic.oup.com/edrv/article/40/4/988/5487357" target="_blank">https://academic.oup.com/edrv/article/40/4/988/5487357</a>).</p><p></p><p>However, although researchers have observed that between individuals HbA1c can vary quite significantly, they also state that within individuals HbA1cs tend to be quite stable. In other words, if your Hba1c is off, it tends to be off by a very similar amount by a similar amount for each HbA1c test.</p><p></p><p>So, in your case if 55 mmol was too high, the previous test of 42 mmol should have been too high too.</p><p></p><p>Why not use a CGM for two weeks to see what your blood sugars are doing throughout the day (and night)?</p></blockquote><p></p>
[QUOTE="ziggy_w, post: 2224739, member: 323454"] Hi [USER=518059]@Lupf[/USER], I've done some research into the topic and yes, HbA1c does not always reflect actual blood sugar levels for individuals. In fact, it can be off quite signficantly. Below is a graphic from the following article, which compares average glucose levels using CGM in mg/dl (divide by 18 to get mmol) and HbA1c: [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521971/[/URL] [IMG]https://www.ncbi.nlm.nih.gov/corecgi/tileshop/tileshop.fcgi?p=PMC3&id=108437&s=70&r=1&c=1[/IMG] Based on this chart, for an HbA1c of 6.3%, for example, average blood glucose readings based on CGM can range from about 110 mg/dl to about 180 mg/dl. Another set of researchers found that HbA1c is out by 7.2 mmol in 40% of individuals. Here's the link to this article: [URL]https://academic.oup.com/edrv/article/40/4/988/5487357[/URL]). However, although researchers have observed that between individuals HbA1c can vary quite significantly, they also state that within individuals HbA1cs tend to be quite stable. In other words, if your Hba1c is off, it tends to be off by a very similar amount by a similar amount for each HbA1c test. So, in your case if 55 mmol was too high, the previous test of 42 mmol should have been too high too. Why not use a CGM for two weeks to see what your blood sugars are doing throughout the day (and night)? [/QUOTE]
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