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Message: <blockquote data-quote="SimonCrox" data-source="post: 1964020" data-attributes="member: 388174">Sorry, but insulin does stimulate the appetite. Many of my patients on rapid analogue insulins found that they just boosted the appetite for that meal dramatically.  One of my friends trialed insulin plus/minus metformin in standard NHS care; over 1 year, those on metfomrin gained 6.1 Kg and those on placebo gained 7.6  kg [ <a href="https://www.ncbi.nlm.nih.gov/pubmed/15842521" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/15842521</a> ].  So one has to take care, unfortunately.Levemir might be less likely to produce weight gain than other basal insulins, and bedtime insulin seems to produce less weight gain than other regimes in T2DM eg Yki-Jarinnen's work (sorry - I spell her name wrong half the time)If you have T2DM, have you considered a GLP-1 RA such as liraglutide instead? These drop glucose as much as insulin, but no hypos per se, and lose weight and decrease risk heart attack/stroke.Best wishes</blockquote>

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