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(Hypo unawareness?) At what levels should you start feeling hypos?
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<blockquote data-quote="Scott-C" data-source="post: 2019792" data-attributes="member: 374531"><p>Hi, [USER=500662]@_rhysmichael[/USER] , that's a bit of a puzzle, but here's a few thoughts on it.</p><p></p><p>4 (or 3.5 in the DAFNE world) has been chosen as the marker for hypos as it's the level (probably better to think of it as a range of "about 4") at which the body's autonomic responses generally kick in to produce adrenalin to trigger the liver into releasing stored glycogen as glucose to raise levels to above 4, and alpha cells in your pancreas will be making glucagon for the same reason. (Incidentally, it's the adrenalin which causes the shakes and sweating, not the low bg.)</p><p></p><p>In T1s, those mechanisms can become blunted, and that's called hypo unawareness.</p><p></p><p>But it usually takes a while for that to happen, years, not months.</p><p></p><p>Which is why it's surprising you're experiencing this so soon.</p><p></p><p>One possibility is that as you're so recently dx'd, you're in the "honeymoon" period where your beta cells get kickstarted back to life, so they and your alpha cells will be working in tandem quite well, so the low isn't really a low at all - it's entirely possible that your liver has already started pushing out glucose to keep you steady but it's just not showed up in stream yet.</p><p></p><p> Another thing which is worth thinking about is basal levels and rate of drop. It might not be true hypo unawareness at all, but perhaps just a slow basal glide hypo.</p><p></p><p>If my bg is dropping rapidly because I've overbolused on bolus fast acting insulin, I'm going to feel that rapid drop and I'll likely feel that long before I reach 4.</p><p></p><p>But if my basal dose is too high, it can result in a slow steady decline in bg, which seems to have the effect of being so slow that it bypasses or sneaks under the radar of the autonomic responses and lead to me being way too low without having patent symptoms.</p><p></p><p>It's not good though, because the next step down can be fits and coma.</p><p></p><p>I had a few experiences in my first few months after dx of a slow glide down and just found myself "woozy" without any shaking. Looking back on it now, I reckon those were maybe too high basal.</p><p></p><p>I've seen the same thing more recently, see pic below. I'd been getting persistent rises after bolus wore off, so thought it's time to play with basal, so ramped it up a bit over a few days.</p><p></p><p>I'd obviously taken it a bit too far when I ended up getting those slow drops over a few hours, repeating themselves after a 6g nudge up, so that was a good clue to tail back the basal dose.</p><p></p><p>[ATTACH=full]32113[/ATTACH]</p><p></p><p>The upshot is that it might be worth discussing with your docs your basal dose amount, doing some basal testing and seeing how it goes from there. Basal testing just involves not eating for about 8 hrs and seeing if bg holds steady. If it drops too much, basal is too high. Having a long lie in on a Saturday is a decent way of doing it.</p><p></p><p>The cgm will help you out a lot with this. If the lows persist, you may have a good case for getting cgm on prescription. Dexcom is good but even better if it's free. If not, see if you can wangle libre on script, then stick a miaomiao transmitter on top, run it to xdrip+ on an android phone or spike on ios, and it's pretty much the same as dex.</p><p></p><p>Two books about cgm which are well worth a look to get the most out of dex:</p><p></p><p>Sugar Surfing, Stephen Ponder</p><p></p><p>Beyond Fingersticks..., William Lee Dubois</p><p></p><p>Good luck, cgm makes this game much easier!</p></blockquote><p></p>
[QUOTE="Scott-C, post: 2019792, member: 374531"] Hi, [USER=500662]@_rhysmichael[/USER] , that's a bit of a puzzle, but here's a few thoughts on it. 4 (or 3.5 in the DAFNE world) has been chosen as the marker for hypos as it's the level (probably better to think of it as a range of "about 4") at which the body's autonomic responses generally kick in to produce adrenalin to trigger the liver into releasing stored glycogen as glucose to raise levels to above 4, and alpha cells in your pancreas will be making glucagon for the same reason. (Incidentally, it's the adrenalin which causes the shakes and sweating, not the low bg.) In T1s, those mechanisms can become blunted, and that's called hypo unawareness. But it usually takes a while for that to happen, years, not months. Which is why it's surprising you're experiencing this so soon. One possibility is that as you're so recently dx'd, you're in the "honeymoon" period where your beta cells get kickstarted back to life, so they and your alpha cells will be working in tandem quite well, so the low isn't really a low at all - it's entirely possible that your liver has already started pushing out glucose to keep you steady but it's just not showed up in stream yet. Another thing which is worth thinking about is basal levels and rate of drop. It might not be true hypo unawareness at all, but perhaps just a slow basal glide hypo. If my bg is dropping rapidly because I've overbolused on bolus fast acting insulin, I'm going to feel that rapid drop and I'll likely feel that long before I reach 4. But if my basal dose is too high, it can result in a slow steady decline in bg, which seems to have the effect of being so slow that it bypasses or sneaks under the radar of the autonomic responses and lead to me being way too low without having patent symptoms. It's not good though, because the next step down can be fits and coma. I had a few experiences in my first few months after dx of a slow glide down and just found myself "woozy" without any shaking. Looking back on it now, I reckon those were maybe too high basal. I've seen the same thing more recently, see pic below. I'd been getting persistent rises after bolus wore off, so thought it's time to play with basal, so ramped it up a bit over a few days. I'd obviously taken it a bit too far when I ended up getting those slow drops over a few hours, repeating themselves after a 6g nudge up, so that was a good clue to tail back the basal dose. [ATTACH=full]32113[/ATTACH] The upshot is that it might be worth discussing with your docs your basal dose amount, doing some basal testing and seeing how it goes from there. Basal testing just involves not eating for about 8 hrs and seeing if bg holds steady. If it drops too much, basal is too high. Having a long lie in on a Saturday is a decent way of doing it. The cgm will help you out a lot with this. If the lows persist, you may have a good case for getting cgm on prescription. Dexcom is good but even better if it's free. If not, see if you can wangle libre on script, then stick a miaomiao transmitter on top, run it to xdrip+ on an android phone or spike on ios, and it's pretty much the same as dex. Two books about cgm which are well worth a look to get the most out of dex: Sugar Surfing, Stephen Ponder Beyond Fingersticks..., William Lee Dubois Good luck, cgm makes this game much easier! [/QUOTE]
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