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Message: <blockquote data-quote="Silvermagic" data-source="post: 694475" data-attributes="member: 87943">There are hundreds of different antidepressants available, but with all of them, there is a period of adjustment where your body has to get used to them. Usually its best to start with a lower dose and gradually build up until you have the result you are hoping for. I can't get on with sertraline, but an older one, amitryptilene, works well for me and reduces pain. The important thing is to stay in close contact with the medical person who is managing your diabetes. There is no one drug that is right for everyone and they want you to feel well as much as you do. Most surgeries offer phone consultations these days so you don't really have to go to the surgery very often.  Keeping the lines of communication open is probably the best advice.Good luck.</blockquote>

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