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<blockquote data-quote="ME_Valentijn" data-source="post: 1389284"><p>The research demonstrating that supplementation (or a diet with a decent amount vegetables) corrects for the increased risk of birth defects was using normal supplements, not methylfolate. Increased amount of the substrate (folic acid) might result in improved methylation even when enzyme activity is impaired. Though large amounts of folic acid also might block the body's use of active folate.</p><p></p><p>My own preference would be eating more vegetables, and supplementing a small amount of an active methylfolate. But the research indicates that folic acid is probably sufficient.</p></blockquote><p></p>
[QUOTE="ME_Valentijn, post: 1389284"] The research demonstrating that supplementation (or a diet with a decent amount vegetables) corrects for the increased risk of birth defects was using normal supplements, not methylfolate. Increased amount of the substrate (folic acid) might result in improved methylation even when enzyme activity is impaired. Though large amounts of folic acid also might block the body's use of active folate. My own preference would be eating more vegetables, and supplementing a small amount of an active methylfolate. But the research indicates that folic acid is probably sufficient. [/QUOTE]
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