Thirsty
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Lowering blood sugar levels too far when treating type 2 diabetes can be as dangerous as allowing it to remain high, according to UK researchers.
Cardiff University researchers looked at GP data on nearly 50,000 diabetes patients aged over 50, who had had their treatment regimen intensified to either a combination of oral therapies or a combination including insulin.
They compared all cause mortality between the two treatment groups.
They found the results showed a “u-shaped” pattern, with those with the lowest HbA1c levels (average 6.4 per cent) and the highest HbA1c levels (average 10.5 per cent) being the most likely to die from any cause.
The lowest mortality risk was associated with an HbA1c of about 7.5 per cent.
The authors said: “Low and high mean HbA1c values were associated with increased all-cause mortality and cardiac events. If confirmed, diabetes guidelines might need revision to include a minimum HbA1c value.”
Lead researcher Dr Craig Currie added: “Conventionally, doctors have always been told to drive down [HbA1c] as low as possible. It will come as a major surprise to many doctors that taking people down too far appears to be quite risky.”
More research is needed to establish HbA1c thresholds and the combination of drugs to be recommended for intensive treatment, with perhaps differing recommendations according to the patient - intensive treatment seems to be more beneficial for cardiovascular outcomes for those who are younger than 60 years, with a short duration of diabetes, and absence of microvascular and macrovascular disease."
hanadr said:>>
In fact it's a scientific nonsense. Why should a low HbA1c in itself be dangerous? After all non-diabetics have Hba1cs in the range 3.5% to about 6% with an average around 5%. If it's that alone, then non-diabetics should be dropping like flies.
Hana
There is indication that hypoglycaemia contributes to an augmented risk of mortality in patients with diabetes. Intensive glycaemic control increases risk of hypoglycaemia with some drugs more than with others. For that reason, the evaluation of risks associated with the different blood glucose-lowering regimens is essential. The authors in this study looked at the association between all-cause mortality and HbA1c in patients with type 2 diabetes, in a primary-care setting. They then established whether any evident association was independent of the diabetes treatment regimen.
Would the increased risk of heart, stroke and amputations be applicable to diabetics who have "non-diabetic" HbA1cs as a result of diet and exercise alone?Foggitthedoggit said:“Why should a low HbA1c in itself be dangerous?”
The fact that 'normal' people do not appear to be dropping off like flies is neither here nor there. Diabetes, whether we like it or not, is associated to an increased risk of heart and stroke problems (and for some losing their feet), which make us all more vulnerable to an earlier that desired demise.
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cugila said:As this is a thread of interest to Type 2 Diabetics the thread title has been changed to avoid confusion.
It has also been moved to the Type 2 area.
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