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Message: <blockquote data-quote="phoenix" data-source="post: 369087" data-attributes="member: 12578">Re: If this thread helps just ONE person then it will be worI do think that doctors and women  need to be aware that gestational diabetes can be a precursor/risk for  T1 as well as T2. Most of the texts just mention T2.I'm not sure that testing would be that helpful ,at best it would identify some women who might develop T1 within 10 years. It might also produce unnecessary worry to a young mother who may eventually develop T1 but it might be 10 or more years later.  You are right that antibodies in  GD are  a possible indicator of future T1. In  Denmark 75% of those with ICA antibodies and GD eventually developed T1 (not sure of the timescale but it suggests that  25% didn't)  In Germany, 29% of those with at least one antibody developed T1 within 2 years after the birth.In a study  Sweden, they tested all the women who developed GD  in an area for a period of 10 years. There were 385 women  SIx percent (24 out of the 385 women)   were  to be found positive for at least one of the relevant antibodies (islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase antibodies (IA-2A) ).These women were followed for up to 10  years. During this time 50% of them (6 women) developed T1, it is  possible that the rest may do so and  21% of this group had developed impaired fasting or impaired glucose tolerance but it will have take over 10 years.   12.5% (n=6)  of  a matched set of 48  controls ie  women who had GD and were of similar age /weight/ ethnicity etc but had  no antibodies also developed diabetes (T2 in all cases).<a href="http://care.diabetesjournals.org/content/early/2007/05/22/dc07-0157.full.pdf+html" target="_blank">http://care.diabetesjournals.org/conten ... l.pdf+html</a>I'm not sure that you can delay the development. Obviously a healthy lifestyle might increase insulin sensitivity (so the body doesn't need to produce so much insulin)   but I don't think that will affect the autoimmune attack.   Maybe in the future it might be possible to halt or delay beta cell loss.   There are drugs that are undergoing trials (eg one such drug is:  <a href="http://www.andromedabio.com/product.php" target="_blank">http://www.andromedabio.com/product.php</a>  )Some researchers have also suggested that the very early use of insulin can delay true  insulin dependence but someone isn't going to be put on insulin when they still have normal glucose tolerance, only when they start to show some signs of glucose intolerance. Given that GD is a predisposing factor for both types of diabetes, perhaps women who have had GD should have regular checks and  if they develop 'pre diabetes' then they should be tested for antibodies.</blockquote>

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