Immune cell study may explain development of type 1 diabetes

[DCUK NewsBot]

Researchers think they may have discovered an important new development which could explain more about how type 1 diabetes occurs. A team from the University of Eastern Finland say that a certain collection of cells, which are important to the immune system, may play a central role in the development of the condition. Follicular helper T cells are a recently described subset of T cells that have a central role in activating B cells, which in turn are responsible for producing antibodies. The researchers say they have discovered a link between the cells, which were found to have increased at the onset of type 1 diabetes, and the presence of autoantibodies commonly associated with the disease. Type 1 diabetes, which is usually diagnosed in childhood or early adolescence, is an autoimmune disease where the immune system destroys the insulin-producing beta cells in the pancreas. In this study of children with type 1 diabetes, the researchers looked at the frequency of the follicular T helper cells in order to predict a type 1 diagnosis. They also observed a subgroup of children that had tested positive for multiple diabetes-associated autoantibodies. They discovered a connection between the activation of follicular helper T cells and the activation of autoantibody-producing B cells in type 1 diabetes. The study also involved researchers from the Universities of Turku, Helsinki, Tampere and Oulu.

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