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Message: <blockquote data-quote="tim2000s" data-source="post: 1674065" data-attributes="member: 30007">Hi [USER=468065]@Bananas 2[/USER] - what you're describing are the two forms of MDI. The one that many of us started on when it first came out, using NPH and Regular (in Novo terms, Insulatard and ActRapid), which then got moved up to Aspart, Lispro, etc and Glargine or Detemir. It's worth noting in your graphs that Glargine isn't flat like you've presented, and rarely lasts 24 hours. It also suffers an absorption variance that is similar to NPH. Detemir is best used as a twice daily dose due to its peakiness and duration at average doses, rather than a single dose. The other thing I'd note is that your schedule misses a couple of important points. <ol> <li data-xf-list-type="ol">By adjusting the timing of the insulin in relation to the meal, you can account for different meal GIs, such that meal GI plays much less importance, and many people do this.</li> <li data-xf-list-type="ol">Your schedule assumes a uniform absorption in both food and insulin, and this generally isn't the case. </li> </ol></blockquote>

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