JohnEGreen
Master
- Messages
- 14,002
- Location
- Nottinghamshire
- Type of diabetes
- Other
- Treatment type
- Diet only
- Dislikes
- Tripe and Onions
It seems that Imuran (Azathioprine) may be useful in delaying the onset of T1 diabetes and may even bring about short term remission in some cases.
https://www.diabeteshealth.com/imuran-or-insulin/
"About seven years ago, Peggy Polopolus was identified by doctors at the University of Florida Health Center as a person “well on the road to insulin-dependent diabetes.” Her sister was diabetic and Peggy’s insulin was beginning to drop below normal levels. A newly developed test for cell antibodies showed that her immune system was attacking and disabling insulin-producing cells in her pancreas. Doctors gave Peggy twice daily doses of Imuran, and today Peggy is diabetes-free. As a result of Peggy’s success, her doctors are planning a nationwide trial of Imuran on 150 people at high risk for the disease hoping that “if we get people earlier, we may be able to prevent diabetes totally.”"
https://www.uptodate.com/contents/prevention-of-type-1-diabetes-mellitus
"Azathioprine — Azathioprine is an immunosuppressive drug that inhibits or prevents T cell responses to antigens. In one randomized, double-blind study of 46 patients treated with azathioprine and glucocorticoids, insulin could be discontinued in 10 of 20 treated patients as compared with 2 of 20 patients in the placebo group [3]. Endogenous insulin secretion (measured as the plasma C-peptide response to a liquid meal) also improved. However, only three treated patients remained in remission at one year."
Effects seem to be unreliable and short term at the moment but who knows things may improve.
My apologies this is an old article and I had not realized that but shall not delete as some may find it interesting
Not sure how up to date uptodate is.
https://www.diabeteshealth.com/imuran-or-insulin/
"About seven years ago, Peggy Polopolus was identified by doctors at the University of Florida Health Center as a person “well on the road to insulin-dependent diabetes.” Her sister was diabetic and Peggy’s insulin was beginning to drop below normal levels. A newly developed test for cell antibodies showed that her immune system was attacking and disabling insulin-producing cells in her pancreas. Doctors gave Peggy twice daily doses of Imuran, and today Peggy is diabetes-free. As a result of Peggy’s success, her doctors are planning a nationwide trial of Imuran on 150 people at high risk for the disease hoping that “if we get people earlier, we may be able to prevent diabetes totally.”"
https://www.uptodate.com/contents/prevention-of-type-1-diabetes-mellitus
"Azathioprine — Azathioprine is an immunosuppressive drug that inhibits or prevents T cell responses to antigens. In one randomized, double-blind study of 46 patients treated with azathioprine and glucocorticoids, insulin could be discontinued in 10 of 20 treated patients as compared with 2 of 20 patients in the placebo group [3]. Endogenous insulin secretion (measured as the plasma C-peptide response to a liquid meal) also improved. However, only three treated patients remained in remission at one year."
Effects seem to be unreliable and short term at the moment but who knows things may improve.
My apologies this is an old article and I had not realized that but shall not delete as some may find it interesting
Not sure how up to date uptodate is.