Insulin, Aging, And The Brain: Mechanisms And Implications

[kokhongw]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319489/

Abstract
There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. However, the relevance of these to aging and longevity remains to be elucidated. Here, we review advances in our understanding of the physiological role of insulin in the brain, how insulin gets into the brain, and its relevance to aging and longevity. Furthermore, we examine possible future therapeutic applications and implications of insulin in the context of available models of delayed and accelerated aging.

 

[kitedoc]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319489/

Abstract
There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. However, the relevance of these to aging and longevity remains to be elucidated. Here, we review advances in our understanding of the physiological role of insulin in the brain, how insulin gets into the brain, and its relevance to aging and longevity. Furthermore, we examine possible future therapeutic applications and implications of insulin in the context of available models of delayed and accelerated aging.

Thank you @kokhongw, A fascinating article. Diet, exercise, sniffing insulin, ? maybe doing something about those pesky cytokines, and ? gene therapy down the track. Seriously I look forward to more important research and flippantly maybe some great T shirt sayings: Sniff insulin, it is good for you; I have insulin on my brain; Down with Pesky Cytokines; Inflammation Sucks; Brain-food for thought.

 

[kokhongw]

Thank you @kokhongw, A fascinating article. Diet, exercise, sniffing insulin, ? maybe doing something about those pesky cytokines, and ? gene therapy down the track. Seriously I look forward to more important research and flippantly maybe some great T shirt sayings: Sniff insulin, it is good for you; I have insulin on my brain; Down with Pesky Cytokines; Inflammation Sucks; Brain-food for thought.

I think we usually focus mainly on our dysfunctional pancreas. But increasingly there's research showing that insulin action in the brain plays a big part in maintaining glucose homeostasis...especially those by Dr Michael Schwarz's/JM Scarlett UW team on FGF1.

 

[kokhongw]

It remains to be seen if any investors will actually try to develop a suitable FGF1 injectible for our brain...as usual it is ultimately an issue of profitability...
http://theplaidjournal.com/index.php/CoM/article/view/74/79

Additionally, from a commercialization standpoint, FGF-1 is in the public domain and cannot be patented. Thus, resources spent to develop it as a drug can potentially be immediately circumvented by a competing generic form. In the absence of patent protection (i.e. without “a composition of matter” patent) no investor will commit to drug development. Fortunately, the variants of FGF-1 that we have developed are patentable. FSU has been issued a number of patents for these variants, and has also successfully licensed this intellectual property to interested commercial partners. Additionally, we recently published a 2016 report on a mutant FGF-1 that might serve as a lead compound in the novel treatment of type 2 diabetes [8].

 

[kitedoc]

It remains to be seen if any investors will actually try to develop a suitable FGF1 injectible for our brain...as usual it is ultimately an issue of profitability...
http://theplaidjournal.com/index.php/CoM/article/view/74/79

Thank you for this too. I like the comment that not may people have to have injections in to their brain! So interesting times ahead and commercially I guess the intra-nasal route is the way to go. Fingers crossed.
It would also be interesting to know what effect cytokine formation might have on FGF -1 and its effects on glucose and fat regulation and if so wether this is another approach of benefit.

 

[Cobia]

It remains to be seen if any investors will actually try to develop a suitable FGF1 injectible for our brain...as usual it is ultimately an issue of profitability...
http://theplaidjournal.com/index.php/CoM/article/view/74/79

I ran into 2 studies on Alzimers patients on this very topic. One was done in 2014 the other was done in 2016. I think they are only just begining to see what insulin does with the brain.

One thing they came up with was insulin resistance in the BBB and the delivery method was intra nasle to bypass the brain blood barrier.

The thread i started i think in dec had them.

If you want send me a pm i may have something to add off the forum.

 

[kokhongw]

I ran into 2 studies on Alzimers patients on this very topic. One was done in 2014 the other was done in 2016. I think they are only just begining to see what insulin does with the brain.

One thing they came up with was insulin resistance in the BBB and the delivery method was intra nasle to bypass the brain blood barrier.

The thread i started i think in dec had them.

My memories fails me. I couldn't recall the discussion we had till I search and reread the earlier thread. In fact that is why I choose to post regularly on the forum...somethings without actually engaging in a discussion, it is more to have a place to keep track of key ideas/articles that I have come across where it is searchable or some one else can remember ...some form of collective memory.

https://www.diabetes.co.uk/forum/threads/insulin-for-the-brain.130714/


This current thread is a good followup...

In any case I have been intrigued by how much T2D had noticeably deteriorated my brain over the years and looking for ways to halt that and restore its sharpness.

At the end of the day, much of what we have been designed to do centers around feeding and nourishing our brain.