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Message: <blockquote data-quote="Spiker" data-source="post: 840481" data-attributes="member: 102150">Ok I see in your manifesto where you do fit to a scatter diagram and get an improving R^2 numbers as you add in net carbs and protein. For me I need to see some more heavyweight stats tests applied to your data because to be honest, by eye I don't see the scatter plot tightening that much around the trend line. As a T1, importantly, I could not afford to dose insulin with that much uncertainty. Having said that, if FII is correct, I already am! <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile    :)" loading="lazy" data-shortname=":)" /> You say it's "conventional wisdom" to dose about 50% for protein. I would say that is wrong, there is no conventional wisdom. There are very few people dosing for protein and almost no agreement as to how to do it. I will tell you for a fact that your 0.54 ratio will not work for me and will make me go hypo. I know this from repeated experience. You say that the basis of the conventional wisdom is unclear. I can tell you where it comes from: Dr Bernstein. Start by reading his book. Actually don't. I read 3 editions of his book cover to cover trying to accurately summarise what he says about protein dosing. It was inconsistent. And he is the authoritative source for low carb T1s. He cites a number of 58%, similar to your 0.54. He does not cite any paper. You cite a number of 0.54 from a paper of 1920. Before insulin was isolated, incidentally. I contacted Bernstein directly and he did not resolve the question directly. Except he did. Because he gave the best and correct answer which is "it depends".  Never good when a lawyer says that and much worse when your doctor tells you that. But it depends. Apart from anything else it is completely unknown how much protein will enter gluconeogenesis and be converted to glucose. (I take it you know that's why protein causes an insulin effect.) It totally varies from individual to individual and from day to day in the same individual. This is because protein is also used structurally and that value can be estimated but not known. And a variety of different inconsistent formulas exist even for estimating it. So an unknown variable part of the protein will not undergo GNG. . GNG is also a variable process that is down regulated by insulin. Another unknown. So to summarise I will say this is what I believe about protein dosing:- varies by individual - varies within individual over time - absolute maximum GNG of 58%- carb diet raises insulin and suppresses GNG - protein diet to a lesser extent probably suppresses GNG (self -  suppresses) - base protein demand for structural protein needs to be discounted from GNG - base protein demand varies widely and is hard to estimate or measure with any confidence - in practice, ignore protein unless low carbing - test and titrate to find your personal protein ratio just as you would test and titrate to find your other insulin ratios - be observant for ratio changes, as you would be with other insulin ratios</blockquote>

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