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insulin resistance question to clarify situation.please
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<blockquote data-quote="phoenix" data-source="post: 427233" data-attributes="member: 12578"><p>Insulin doesn't just help admit glucose to the cells. It is actually possible for skeletal and muscle cells to use glucose without insulin. Muscle cell insulin transporters react to both exercise and to insulin, If one is exercising then they don't need insulin. That's why those of us using insulin have to be careful not to take too much whilst exercising.</p><p>A second function of insulin is the one that is thought to produce most problems with high glucose.Insulin ( in parallel with another hormone, glucagon)also serves to control the release of glucose from the liver. If there is insufficient insulin then the liver will 'think' that the cells need more glucose and release it . <a href="http://science.howstuffworks.com/life/human-biology/diabetes1.htm" target="_blank">http://science.howstuffworks.com/life/h ... betes1.htm</a></p><p> If the cells in the liver are insulin resistant (and they are thought to be made so by excess fat) then some people can produce and release 3 times more glucose from the liver than non diabetics: Metformin helps to reduce this hepatic (liver) insulin production/release. <a href="http://diabetes.diabetesjournals.org/content/49/12/2063.full.pdf+html" target="_blank">http://diabetes.diabetesjournals.org/co ... l.pdf+html</a>. This is one reason that many treatments including the 'Newcastle' diet focus on reducing fat around the organs</p><p></p><p></p><p>Lantus is a background insulin . It's whole purpose is to deal with the glucose produced from your liver. If you have insulin resistance, then you will need higher doses.</p><p>The academic answer to reduce background insulin dose is to reduce any excess fat around the liver and other organs. </p><p>Pragmatically , you need to use sufficient insulin to control high background glucose levels to help prevent subsequent problems</p></blockquote><p></p>
[QUOTE="phoenix, post: 427233, member: 12578"] Insulin doesn't just help admit glucose to the cells. It is actually possible for skeletal and muscle cells to use glucose without insulin. Muscle cell insulin transporters react to both exercise and to insulin, If one is exercising then they don't need insulin. That's why those of us using insulin have to be careful not to take too much whilst exercising. A second function of insulin is the one that is thought to produce most problems with high glucose.Insulin ( in parallel with another hormone, glucagon)also serves to control the release of glucose from the liver. If there is insufficient insulin then the liver will 'think' that the cells need more glucose and release it . [url=http://science.howstuffworks.com/life/human-biology/diabetes1.htm]http://science.howstuffworks.com/life/h ... betes1.htm[/url] If the cells in the liver are insulin resistant (and they are thought to be made so by excess fat) then some people can produce and release 3 times more glucose from the liver than non diabetics: Metformin helps to reduce this hepatic (liver) insulin production/release. [url=http://diabetes.diabetesjournals.org/content/49/12/2063.full.pdf+html]http://diabetes.diabetesjournals.org/co ... l.pdf+html[/url]. This is one reason that many treatments including the 'Newcastle' diet focus on reducing fat around the organs Lantus is a background insulin . It's whole purpose is to deal with the glucose produced from your liver. If you have insulin resistance, then you will need higher doses. The academic answer to reduce background insulin dose is to reduce any excess fat around the liver and other organs. Pragmatically , you need to use sufficient insulin to control high background glucose levels to help prevent subsequent problems [/QUOTE]
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